European Journal of Clinical Microbiology & Infectious Diseases

, Volume 29, Issue 3, pp 259–267

Safety and immunogenicity of an investigational quadrivalent meningococcal conjugate vaccine after one or two doses given to infants and toddlers

  • S. A. Halperin
  • F. Diaz-Mitoma
  • P. Dull
  • A. Anemona
  • F. Ceddia
Article

DOI: 10.1007/s10096-009-0848-8

Cite this article as:
Halperin, S.A., Diaz-Mitoma, F., Dull, P. et al. Eur J Clin Microbiol Infect Dis (2010) 29: 259. doi:10.1007/s10096-009-0848-8

Abstract

With the emergence of multiple meningococcal serogroups in different geographic areas, broad vaccine protection from infancy is desirable. One hundred and seventy-five infants received either two doses of a meningococcal quadrivalent (A, C, W-135, Y) conjugate vaccine (MenACWY-CRM) at 6 and 12 months, one dose of MenACWY-CRM at 12 months, or MenC at 12 months and MenACWY-CRM at 18 months. Bactericidal antibody titers using human complement were measured before and 1 month after each dose. Injection-site reactions were reported by 22–45% of participants following MenACWY-CRM given at 6 or 12 months. Similar proportions of subjects had injection-site reactions following two doses of MenACWY-CRM (32–41%) or one dose of MenC (26–44%). The incidence of systemic adverse events was comparable between groups. After two doses of MenACWY-CRM, the percentages of participants reporting hSBA titers ≥8 were 100% for C, W-135, and Y, and 84% for A. Serogroup C titers were more than 10-fold higher after two doses of MenACWY-CRM than after one dose of MenC or MenACWY-CRM at 12 months. Serogroup C titers were comparable following a single dose of MenACWY-CRM or MenC at 12 months. MenACWY-CRM is well tolerated and immunogenic given at 12 months, or two doses at 6 and 12 months of age.

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • S. A. Halperin
    • 1
  • F. Diaz-Mitoma
    • 2
  • P. Dull
    • 3
  • A. Anemona
    • 3
  • F. Ceddia
    • 3
  1. 1.Clinical Trials Research Center, Canadian Center for VaccinologyDalhousie University and the IWK Health CentreHalifaxCanada
  2. 2.Children’s Hospital of Eastern OntarioOttawaCanada
  3. 3.Novartis VaccinesSienaItaly