Comparison of community-associated meticillin-resistant Staphylococcus aureus from teaching hospitals in London and the USA, 2004–2006: where is USA300 in the UK?

  • J. A. Otter
  • N. L. Havill
  • J. M. Boyce
  • G. L. French
Brief Report

DOI: 10.1007/s10096-008-0698-9

Cite this article as:
Otter, J.A., Havill, N.L., Boyce, J.M. et al. Eur J Clin Microbiol Infect Dis (2009) 28: 835. doi:10.1007/s10096-008-0698-9

Abstract

Community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly common in the USA, but rare in the UK. We compared CA-MRSA from the UK and USA to examine differences in the molecular epidemiology. We investigated patients presenting with MRSA in the first 72 h of hospital admission or in out-patient settings in a UK and a US hospital from January 2004 to March 2006. Fluoroquinolone susceptibility was used as a screening marker to select presumptive CA-MRSA. One hundred and eighteen and 49 such strains were identified, representing a prevalence of 0.1 and 0.2 isolates per 1,000 patient days in the UK and US respectively. Panton–Valentine leukocidin (PVL)-positive ST8-IVa (USA300)-type strains predominated among 43 surviving US isolates, whereas PVL-negative ST1-IVa predominated among 71 surviving UK isolates. There are striking differences between the molecular epidemiology of CA-MRSA in UK and US hospitals, which may have implications for control.

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • J. A. Otter
    • 1
  • N. L. Havill
    • 2
  • J. M. Boyce
    • 2
    • 3
  • G. L. French
    • 1
    • 4
  1. 1.Guy’s and St. Thomas’ Hospital and King’s College LondonLondonUK
  2. 2.Hospital of Saint RaphaelNew HavenUSA
  3. 3.Yale University School of MedicineNew HavenUSA
  4. 4.Department of Infection, 5th Floor, North WingGuy’s and St. Thomas’ Hospital and King’s College LondonLondonUK

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