Concise Article

European Journal of Clinical Microbiology & Infectious Diseases

, Volume 28, Issue 4, pp 399-402

First online:

Effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to tenofovir-emtricitabine (TDF-FTC) co-formulation (Truvada®) in virologically suppressed HIV-infected patients on HAART

  • R. PalaciosAffiliated withUnidad de Enfermedades Infecciosas, Hosp. Virgen de la Victoria
  • , C. HidalgoAffiliated withHosp. Virgen de las Nieves
  • , M. J. RíosAffiliated withHosp. Virgen Macarena
  • , A. RiveroAffiliated withHosp. Reina Sofía
  • , L. MuñozAffiliated withHosp. San Cecilio
  • , F. LozanoAffiliated withHosp. de Valme
  • , V. Gutiérrez-RavéAffiliated withHosp. de Motril
  • , M. C. GálvezAffiliated withHosp. Torrecárdenas
  • , A. del ArcoAffiliated withHosp. Costa del Sol

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The objective was to evaluate the effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to Truvada® (TVD) in virologically suppressed HIV patients. We carried out an open-label, multicentre, non-controlled study of HIV patients on a stable regimen including TDF-3TC who switched from TDF-3TC to TVD. Viral load responses at 24 and 48 weeks were evaluated. Changes in the calculated glomerular filtration rates (cGFR; Cockcroft-Gault equation) were analysed at baseline and at 24 and 48 weeks. Patients with drug-related nephrotoxicity (cGFR < 60 mL/min at 48 weeks or interruption of TVD because of renal toxicity) were analysed in detail. Two hundred and ninety-five patients with a mean time on TDF-3TC of 19.9 months (range 8.8–29.8) were enrolled. The third drug was a non-nucleoside reverse transcriptase inhibitor, which was administered to 187 patients (76.4% efavirenz) and a protease inhibitor was administered to 108 (43.5% lopinavir/ritonavir). At 48 weeks, 85.7% of the patients were still taking the same regimen, all with an undetectable viral load. The cGFR (mL/min) decreased from baseline (111 [89–130]) to 48 weeks (105 [84–121]); p < 0.0001. The percentage of patients with a cGFR <60 mL/min at 48 weeks was 3.5. Six patients ceased TVD because of drug-related nephrotoxicity. The only factors associated with nephrotoxicity were age, baseline weight and cGFR. Simplification from TDF-3TC to TVD was associated with a decrease in cGFR, with a low prevalence of nephrotoxicity at 48 weeks.