European Journal of Clinical Microbiology & Infectious Diseases

, 28:353

Community-associated versus healthcare-associated methicillin-resistant Staphylococcus aureus bacteraemia: a 10-year retrospective review

Authors

    • Department of Microbiology and Infectious DiseasesPathWest Laboratory Medicine, Royal Perth Hospital
  • J. C. Pearson
    • Department of Microbiology and Infectious DiseasesPathWest Laboratory Medicine, Royal Perth Hospital
  • K. J. Christiansen
    • Department of Microbiology and Infectious DiseasesPathWest Laboratory Medicine, Royal Perth Hospital
    • Gram-positive Bacteria Typing and Research Unit, School of Biomedical SciencesCurtin University of Technology
  • G. W. Coombs
    • Department of Microbiology and Infectious DiseasesPathWest Laboratory Medicine, Royal Perth Hospital
    • Gram-positive Bacteria Typing and Research Unit, School of Biomedical SciencesCurtin University of Technology
  • R. J. Murray
    • Department of Microbiology and Infectious DiseasesPathWest Laboratory Medicine, Royal Perth Hospital
Article

DOI: 10.1007/s10096-008-0632-1

Cite this article as:
Robinson, J.O., Pearson, J.C., Christiansen, K.J. et al. Eur J Clin Microbiol Infect Dis (2009) 28: 353. doi:10.1007/s10096-008-0632-1

Abstract

The objective was to compare the epidemiology and outcome of healthcare- (HA-) and community-associated (CA-) MRSA bacteraemia. A 10-year retrospective study of MRSA bacteraemia was carried out. Episodes were classified according to established criteria. Molecular typing was performed on a subset of isolates. Of 197 MRSA bacteraemia episodes, 178 (90.4%) were classified as HA-MRSA and 19 (9.6%) as CA-MRSA. All-cause 7- and 30-day mortality rates were similar in the HA and CA-MRSA bacteraemia groups; however, 1-year mortality was higher in the HA-MRSA bacteraemia group (48.3% vs 21.1% [p = 0.023]). Thirty-day all-cause mortality was significantly lower if empiric antimicrobial therapy included agent(s) to which the isolate tested susceptible, compared with patients receiving “inactive” therapy (19% vs 35.1% [p = 0.011]). The majority of MRSA bacteraemia episodes were caused by clones known to circulate in the community. All-cause mortality is as high in HA- as in CA-MRSA bacteraemia. Thirty-day mortality was significantly reduced if the patient received an antibiotic with activity against the MRSA isolate.

Copyright information

© Springer-Verlag 2008