Disseminated cryptococcosis in HIV-uninfected patients

  • Y.-M. Chuang
  • Y.-C. Ho
  • H.-T. Chang
  • C.-J. Yu
  • P.-C. Yang
  • P.-R. Hsueh
Concise Article

DOI: 10.1007/s10096-007-0430-1

Cite this article as:
Chuang, YM., Ho, YC., Chang, HT. et al. Eur J Clin Microbiol Infect Dis (2008) 27: 307. doi:10.1007/s10096-007-0430-1

Abstract

Cryptococcus neoformans usually causes disease in patients with human immunodeficiency virus (HIV) infection. This descriptive study was based on a retrospective review of 33 HIV-uninfected patients with disseminated cryptococcosis from 1998 to 2005. An underlying condition associated with immunocompromise was documented in 30 patients (90.9%), including liver cirrhosis (36.4%), diabetes mellitus (33.3%) and autoimmune disease (27.3%). Disseminated cryptococcosis carried a high mortality rate in this series, reaching 63% overall, with a median survival of 21 days. All patients (12/12) with liver cirrhosis died within the first month after the diagnosis of cryptococcosis. Otherwise, high Acute Physiology and Chronic Health Evaluation II (APACHE II) score, female gender and smoking history were associated with worse one-month outcome.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Y.-M. Chuang
    • 1
  • Y.-C. Ho
    • 2
  • H.-T. Chang
    • 3
  • C.-J. Yu
    • 2
  • P.-C. Yang
    • 2
  • P.-R. Hsueh
    • 2
    • 4
  1. 1.Department of Internal MedicineNational Taiwan University Hospital Yun-Lin BranchDouliuTaiwan
  2. 2.Department of Internal MedicineNational Taiwan University Hospital, National Taiwan University Medical CollegeTaipeiTaiwan
  3. 3.Department of Internal MedicineFar Eastern Memorial HospitalTaipei CountyTaiwan
  4. 4.Departments of Laboratory Medicine and Internal MedicineNational Taiwan University Hospital, National Taiwan University Medical CollegeTaipeiTaiwan

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