The anti-cancer effects of quinolone antibiotics?

Concise Article

DOI: 10.1007/s10096-007-0375-4

Cite this article as:
Paul, M., Gafter-Gvili, A., Fraser, A. et al. Eur J Clin Microbiol Infect Dis (2007) 26: 825. doi:10.1007/s10096-007-0375-4


A previous meta-analysis showed that quinolones administered for prophylaxis of infections among cancer patients reduced all-cause mortality. We extracted from the primary trials infection-related and all-cause mortality as reported and assessed the effect of quinolones on non-infection-related mortality through meta-analysis. Among trials comparing quinolones to placebo or no treatment, a significant reduction in non-infection-related mortality was observed (relative risk 0.54, 95% confidence interval 0.32–0.93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • M. Paul
    • 1
    • 2
  • A. Gafter-Gvili
    • 1
    • 2
  • A. Fraser
    • 3
  • L. Leibovici
    • 1
    • 2
  1. 1.Department of Medicine E and Infectious Diseases Unit, Rabin Medical CenterBeilinson HospitalPetah-TikvaIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Department of Social MedicineUniversity of BristolBristolUK

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