European Journal of Clinical Microbiology & Infectious Diseases

, Volume 26, Issue 9, pp 635–640

Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome

  • E. Botelho-Nevers
  • P.-E. Fournier
  • H. Richet
  • F. Fenollar
  • H. Lepidi
  • C. Foucault
  • A. Branchereau
  • P. Piquet
  • M. Maurin
  • D. Raoult
Article

DOI: 10.1007/s10096-007-0357-6

Cite this article as:
Botelho-Nevers, E., Fournier, PE., Richet, H. et al. Eur J Clin Microbiol Infect Dis (2007) 26: 635. doi:10.1007/s10096-007-0357-6

Abstract

Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P<0.01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • E. Botelho-Nevers
    • 1
  • P.-E. Fournier
    • 1
  • H. Richet
    • 1
  • F. Fenollar
    • 1
  • H. Lepidi
    • 1
  • C. Foucault
    • 1
  • A. Branchereau
    • 2
  • P. Piquet
    • 3
  • M. Maurin
    • 4
  • D. Raoult
    • 1
  1. 1.Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de MédecineUniversité de la MéditerranéeMarseille Cedex 5France
  2. 2.Service de Chirurgie VasculaireHôpital de la TimoneMarseilleFrance
  3. 3.Service de Chirurgie VasculaireHôpital Sainte-MargueriteMarseilleFrance
  4. 4.Laboratoire de BactériologieHôpital MichallonGrenobleFrance