European Journal of Clinical Microbiology & Infectious Diseases

, Volume 26, Issue 8, pp 557–561

Prevalence, microbiology, and clinical characteristics of extended-spectrum β-lactamase-producing Enterobacter spp., Serratia marcescens, Citrobacter freundii, and Morganella morganii in Korea

Authors

  • S.-H. Choi
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
  • J. E. Lee
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
  • S. J. Park
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
  • M.-N. Kim
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
    • Department of Laboratory Medicine, Asan Medical CenterUniversity of Ulsan College of Medicine
  • E. J. Choo
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
    • Division of Infectious DiseasesSoonchunhyang University Hospital
  • Y. G. Kwak
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
    • Department of Internal Medicine, Ilsanpaik HospitalInje University
  • J.-Y. Jeong
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
  • J. H. Woo
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
  • N. J. Kim
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
    • Division of Infectious Diseases, Asan Medical CenterUniversity of Ulsan College of Medicine
    • Center for Antimicrobial Resistance and Microbial GeneticsUniversity of Ulsan
Article

DOI: 10.1007/s10096-007-0308-2

Cite this article as:
Choi, S., Lee, J.E., Park, S.J. et al. Eur J Clin Microbiol Infect Dis (2007) 26: 557. doi:10.1007/s10096-007-0308-2

Abstract

We examined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL)-producing clinical isolates among Enterobacter spp., Serratia marcescens, Citrobacter freundii, and Morganella morganii, and evaluated screening criteria, clinical characteristics and outcomes of infections caused by ESBL-producing organisms. Between January and June 2005, a total of 493 nonduplicate consecutive isolates were collected at Asan Medical Center, a 2,300-bed tertiary hospital in Seoul, Republic of Korea. Fifty isolates (10.1%) were positive for phenotypical ESBL-test. The positive rate of phenotypical ESBL-test in Enterobacter spp., S. marcescens, C. freundii, and M. morgannii was 12.8%, 12.4%, 4.9%, and 0% respectively. SHV-12 (18 isolates), CTX-M-9 (17 isolates), and TEM-52 (five isolates) were the most prevalent ESBL types. The ESBL in 17 strains could not be identified. As an ESBL screening criterion, the cefepime MIC ≥1 μg/ml had the highest sensitivity (0.84) and specificity (0.87). Half of the ESBL-producing isolates (25/50) were judged as pathogens. Cholangitis (ten cases), and pneumonia (six cases) were the most common infections. The overall mortality was 12.0%.

Copyright information

© Springer-Verlag 2007