European Journal of Clinical Microbiology & Infectious Diseases

, Volume 26, Issue 4, pp 281–286

High frequency of Panton-Valentine leukocidin genes in invasive methicillin-susceptible Staphylococcus aureus strains and the relationship with methicillin-resistant Staphylococcus aureus in Córdoba, Argentina

  • C. Sola
  • H. A. Saka
  • A. Vindel
  • J. L. Bocco
  • Córdoba S. aureus Collaborative Study Group
Concise Article

DOI: 10.1007/s10096-007-0278-4

Cite this article as:
Sola, C., Saka, H.A., Vindel, A. et al. Eur J Clin Microbiol Infect Dis (2007) 26: 281. doi:10.1007/s10096-007-0278-4

Abstract

In the study presented here, the genetic characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) strains isolated from patients attending hospitals in the city of Córdoba, Argentina, during 1999–2002 were evaluated to determine their genetic relationship with methicillin-resistant S. aureus (MRSA) clones as part of an effort to control the potential emergence of new epidemic MRSA strains. The results showed there is a high frequency of MSSA strains carrying Panton-Valentine leukocidin genes in invasive infections in Córdoba, Argentina, particularly in those occurring in hospital settings. Panton-Valentine leukocidin genes were found in the genomic background of one clone (ST30-N pulsotype) belonging to a successful internationally distributed MSSA lineage (clonal complex 30), which is closely related to the EMRSA-16 pandemic clone. These genes were also detected in the ancestral clone (ST5-M pulsotype) of the most prevalent MRSA epidemic clone causing healthcare-associated infections in this region, known as the Cordobes/Chilean clone. The molecular characterization of circulating MSSA strains, including the detection of Panton-Valentine leukocidin genes, is thus a useful marker for investigating the evolving epidemiology of hospital- and community-acquired MRSA clones.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • C. Sola
    • 1
  • H. A. Saka
    • 1
  • A. Vindel
    • 2
  • J. L. Bocco
    • 1
  • Córdoba S. aureus Collaborative Study Group
  1. 1.Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI—CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCórdobaArgentina
  2. 2.Laboratorio de Enfermedades Infecciosas NosocomialesInstituto de Salud Carlos III, Centro Nacional de MicrobiologíaMajadahonda, MadridSpain