European Journal of Clinical Microbiology & Infectious Diseases

, Volume 26, Issue 3, pp 213–216

Comparison of antibiotic susceptibility of Burkholderia cepacia complex organisms when grown planktonically or as biofilm in vitro

  • E. Caraher
  • G. Reynolds
  • P. Murphy
  • S. McClean
  • M. Callaghan
Concise Article

DOI: 10.1007/s10096-007-0256-x

Cite this article as:
Caraher, E., Reynolds, G., Murphy, P. et al. Eur J Clin Microbiol Infect Dis (2007) 26: 213. doi:10.1007/s10096-007-0256-x

Abstract

This study determined the antibiotic susceptibility of planktonic and biofilm cultures of Burkholderia cepacia complex organisms, a group of highly problematic pathogens associated with cystic fibrosis patients. The biofilm inhibitory concentrations were considerably higher than the corresponding minimum inhibitory concentrations for meropenem and piperacillin-tazobactam. However, tobramycin and amikacin were efficacious against both biofilm and planktonic cultures. Overall this study showed that biofilm susceptibility testing might be more clinically appropriate for determining antibiotic therapy for Burkholderia cepacia complex infections in cystic fibrosis patients.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • E. Caraher
    • 1
  • G. Reynolds
    • 1
  • P. Murphy
    • 2
    • 3
  • S. McClean
    • 1
  • M. Callaghan
    • 1
  1. 1.Department of Applied Science and National Institute of Cellular Biotechnology (NICB)Institute of Technology Tallaght (ITT-Dublin)Dublin 24Ireland
  2. 2.The AdelaideMeath Incorporating the National Children’s Hospital (AMNCH)Dublin 24Ireland
  3. 3.Department of Clinical MicrobiologyTrinity CollegeDublin 2Ireland