Macrolide use identified as risk factor for macrolide-resistant Streptococcus pneumoniae in a 17-center case-control study

  • S. E. Beekmann
  • D. J. Diekema
  • K. P. Heilmann
  • S. S. Richter
  • G. V. Doern
Concise Article

DOI: 10.1007/s10096-006-0137-8

Cite this article as:
Beekmann, S.E., Diekema, D.J., Heilmann, K.P. et al. Eur J Clin Microbiol Infect Dis (2006) 25: 335. doi:10.1007/s10096-006-0137-8

Abstract

The objective of the case-control study presented here was to examine the risk factors for macrolide-resistant Streptococcus pneumoniae. As part of a 44-center U.S. surveillance study, 1,817 unique isolates of S. pneumoniae were collected from November 2002 through April 2003. Seventy-five randomly selected macrolide-resistant isolates (cases) were each matched with one susceptible control. Macrolide use in the 6 weeks prior to sample collection was reported for seven cases and one control. The final conditional logistic regression model identified two statistically significant variables: a history of alcohol abuse was protective, while macrolide use in the 6 weeks prior to sample collection was a significant risk factor for macrolide-resistant S. pneumoniae. Macrolide resistance was associated with use of any antibiotic during the prior 6 weeks, and was most strongly associated with previous macrolide use.

Keywords

Streptococcus pneumoniae Macrolide resistance Case-control study 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • S. E. Beekmann
    • 1
  • D. J. Diekema
    • 1
    • 2
  • K. P. Heilmann
    • 1
  • S. S. Richter
    • 1
  • G. V. Doern
    • 1
  1. 1.Division of Medical Microbiology, Department of Pathology 265 MRCUniversity of IowaIowaUSA
  2. 2.Division of Infectious Diseases, Department of Internal MedicineRoy J. and Lucille A. Carver University of Iowa College of MedicineIowa CityUSA