Sensitivity of urinary antigen test in relation to clinical severity in a large outbreak of Legionella pneumonia in Spain

  • R. M. Blázquez
  • F. J. Espinosa
  • C. M. Martínez-Toldos
  • L. Alemany
  • M. C. García-Orenes
  • M. Segovia
Concise Article

DOI: 10.1007/s10096-005-1361-3

Cite this article as:
Blázquez, R.M., Espinosa, F.J., Martínez-Toldos, C.M. et al. Eur J Clin Microbiol Infect Dis (2005) 24: 488. doi:10.1007/s10096-005-1361-3

Abstract

Presented here are the results of Legionella urinary antigen testing correlated with patient characteristics and severity of pneumonia (Fine score) in 295 patients diagnosed with Legionella pneumonia in connection with a large outbreak in Murcia, Spain. Overall, the sensitivity of the urinary antigen test was 47.7% (141/295). A statistically significant association was found between the clinical severity of pneumonia and test sensitivity; 85.7% for patients with severe pneumonia versus 37.9% for patients with mild pneumonia (risk ratio, 2.3). Variables significantly associated with test positivity in multivariate analysis were as follows: pre-existing pulmonary disease, body temperature >40°C, leukocytosis and multilobar infiltrates. Patients with mild pneumonia may go undiagnosed if the urinary antigen test is used alone.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • R. M. Blázquez
    • 1
  • F. J. Espinosa
    • 1
  • C. M. Martínez-Toldos
    • 2
  • L. Alemany
    • 3
  • M. C. García-Orenes
    • 4
  • M. Segovia
    • 2
    • 5
  1. 1.Section of Infectious DiseasesHospital “J.M. Morales Meseguer”MurciaSpain
  2. 2.Service of MicrobiologyHospital “J.M. Morales Meseguer”MurciaSpain
  3. 3.Section of Respiratory DiseasesHospital “J.M. Morales Meseguer”MurciaSpain
  4. 4.Service of Internal MedicineHospital “J.M. Morales Meseguer”MurciaSpain
  5. 5.Department of Genetics and MicrobiologyUniversity of MurciaMurciaSpain

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