European Journal of Clinical Microbiology and Infectious Diseases

, Volume 24, Issue 1, pp 31–40

Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases

  • J. P. Cannon
  • T. A. Lee
  • J. T. Bolanos
  • L. H. Danziger

DOI: 10.1007/s10096-004-1253-y

Cite this article as:
Cannon, J.P., Lee, T.A., Bolanos, J.T. et al. Eur J Clin Microbiol Infect Dis (2005) 24: 31. doi:10.1007/s10096-004-1253-y


Given that Lactobacillus has been reported to be the causative pathogen in many types of infection despite debate regarding the organism’s clinical significance, a literature review was conducted to investigate the treatments and outcomes of Lactobacillus infections reported to date. In this article, the characteristics of over 200 reported cases of Lactobacillus-associated infections are summarized. Lactobacillus was found to be frequently associated with endocarditis and bacteremia. Lactobacillus was also associated with a variety of other infections including, but not limited to, peritonitis, abscesses, and meningitis. The species casei and rhamnosus were the most common. The isolates tended to be most sensitive to erythromycin and clindamycin and most resistant to vancomycin. The species that was most sensitive to vancomycin was acidophilus. The overall mortality rate was nearly 30%. There was a significant association between mortality and polymicrobial infection (P=0.004). In the subset of patients with bacteremia, increased mortality was associated with inadequate treatment (P=0.001) and polymicrobial bacteremia (P=0.044).

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • J. P. Cannon
    • 1
  • T. A. Lee
    • 2
    • 3
    • 4
  • J. T. Bolanos
    • 6
  • L. H. Danziger
    • 5
  1. 1.Edward Hines, Jr. VA HospitalPharmacy ServiceHinesUSA
  2. 2.Midwest Center for Health Services and Policy ResearchEdward Hines, Jr. VA HospitalHinesUSA
  3. 3.Center for Healthcare Studies, Division of General Internal Medicine, Department of MedicineNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.Center for Pharmacoeconomic Research, College of Pharmacy, 833 South Wood Street (Mail Code 886)University of Illinois at ChicagoChicagoUSA
  5. 5.Department of Pharmacy Practice, College of Pharmacy, 833 South Wood Street (Mail Code 886)University of Illinois at ChicagoChicagoUSA
  6. 6.Department of Medicine, Section of Infectious DiseasesUniversity of Illinois at ChicagoChicagoUSA