European Journal of Clinical Microbiology and Infectious Diseases

, Volume 23, Issue 6, pp 434–444

Epidemiological features of invasive and noninvasive group A streptococcal disease in the Netherlands, 1992–1996

  • B. Vlaminckx
  • W. van Pelt
  • L. Schouls
  • A. van Silfhout
  • C. Elzenaar
  • E. Mascini
  • J. Verhoef
  • J. Schellekens
Article

DOI: 10.1007/s10096-004-1147-z

Cite this article as:
Vlaminckx, B., van Pelt, W., Schouls, L. et al. Eur J Clin Microbiol Infect Dis (2004) 23: 434. doi:10.1007/s10096-004-1147-z

Abstract

A prospective, nationwide, laboratory-based surveillance of invasive group A streptococcal infections was conducted in the Netherlands from 1992 through 1996. Clinical and demographic data were obtained and all isolates were T/M typed. All noninvasive group A streptococcal isolates were registered from 1994 through 1996. A total of 880 patients with invasive streptococcal disease were identified. The annual incidence was found to be 2.2 per 100,000. Predominant M types were M1 (21%), M3 (11%), M6 (5%), M12 (5%), and M28 (8%). Particular age and M-type distributions were observed in different clinical entities. The case-fatality rate was 18% overall, but it reached 59% among cases of toxic shock-like syndrome. Older age, necrotizing fasciitis, sepsis without focus, pneumonia, infection with type M1 or M3 strains, and underlying cardiopulmonary disease were associated with fatality. A total of 10,105 patients with noninvasive group A streptococcal disease were registered. These patients differed significantly from patients with invasive disease with regard to age distribution and primary foci of infection.

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • B. Vlaminckx
    • 1
  • W. van Pelt
    • 2
  • L. Schouls
    • 2
  • A. van Silfhout
    • 2
  • C. Elzenaar
    • 2
  • E. Mascini
    • 1
  • J. Verhoef
    • 1
  • J. Schellekens
    • 2
  1. 1.Eijkman Winkler Institute for Medical Microbiology, Infectious Diseases and InflammationUniversity Medical Center UtrechtUtrechtThe Netherlands
  2. 2.National Institute of Public Health and the Environment (RIVM)BilthovenThe Netherlands