Skip to main content

Advertisement

SpringerLink
Log in

Vitamin D status and Parkinson’s disease: a systematic review and meta-analysis

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

To estimate the associations between vitamin D status and Parkinson’s disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: ‘vitamin D’ or ‘25(OH)D’ and ‘status’ or ‘deficiency’ or ‘insufficiency’ and ‘Parkinson’s disease’. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included. Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), −16.9, 95 % confidence interval (CI)], −33.5 to −0.2). Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1–2.0). Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5–3.4). Low vitamin D levels are associated with an increased risk of PD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Dick FD, De Palma G, Ahmadi A, Scott NW, Prescott GJ, Bennett J, Semple S, Dick S, Counsell C, Mozzoni P, Haites N, Wettinger SB, Mutti A, Otelea M, Seaton A, Söderkvist P, Felice A, Geoparkinson study group (2007) Environmental risk factors for Parkinson’s disease and parkinsonism: the Geoparkinson study. Occup Environ Med 64(10):666–672

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Hancock DB, Martin ER, Mayhew GM, Stajich JM, Jewett R, Stacy MA, Scott BL, Vance JM, Scott WK (2008) Pesticide exposure and risk of Parkinson’s disease: a family-based case–control study. BMC Neurol 8(3):6

    Article  PubMed Central  PubMed  Google Scholar 

  3. Henchcliffe C, Beal MF (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4(11):600–609

    Article  CAS  PubMed  Google Scholar 

  4. DeLuca GC, Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC (2013) Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol 39(5):458–484

    Article  CAS  PubMed  Google Scholar 

  5. Zittermann A, Schleithoff SS, Koerfer R (2006) Vitamin D insufficiency in congestive heart failure: why and what to do about it? Heart Fail Rev 11(1):25–33

    Article  CAS  PubMed  Google Scholar 

  6. Chaudhuri JR, Mridula KR, Alladi S, Anamika A, Umamahesh M, Balaraju B, Swath A, Bandaru VS (2014) Serum 25-hydroxyvitamin D deficiency in ischemic stroke and subtypes in Indian patients. J Stroke 16(1):44–50

    Article  PubMed Central  PubMed  Google Scholar 

  7. Brøndum-Jacobsen P, Nordestgaard BG, Schnohr P, Benn M (2013) 25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis. Ann Neurol 73(1):38–47

    Article  PubMed  Google Scholar 

  8. Martinelli V, Dalla Costa G, Colombo B, Dalla Libera D, Rubinacci A, Filippi M, Furlan R, Comi G (2014) Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes. Mult Scler 20(2):147–155

    Article  CAS  PubMed  Google Scholar 

  9. Guzmán-Fulgencio M, García-Álvarez M, Berenguer J, Jiménez-Sousa MÁ, Cosín J, Pineda-Tenor D, Carrero A, Aldámiz T, Alvarez E, López JC, Resino S (2014) Vitamin D deficiency is associated with severity of liver disease in HIV/HCV coinfected patients. J Infect 68(2):176–184

    Article  PubMed  Google Scholar 

  10. Camargo CA Jr, Manson JE (2014) Vitamin D supplementation and risk of infectious disease: no easy answers. Am J Clin Nutr 99(1):3–4

    Article  CAS  PubMed  Google Scholar 

  11. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF (2007) Optimal vitamin D status for colorectal cancer prevention: a quantitative meta-analysis. Am J Prev Med 32(3):210–216

    Article  PubMed  Google Scholar 

  12. Evatt ML (2010) Beyond vitamin status: is there a role for vitamin D in Parkinson disease? Arch Neurol 67(7):795–797

    PubMed  Google Scholar 

  13. Newmark HL, Newmark J (2007) Vitamin D and Parkinson’s disease––a hypothesis. Mov Disord 22(4):461–468

    Article  PubMed  Google Scholar 

  14. Evatt ML, DeLong MR, Kumari M, Auinger P, McDermott MP, Tangpricha V, Parkinson Study Group DATATOP Investigators (2011) High prevalence of hypovitaminosis D status in patients with early Parkinson disease. Arch Neurol 68(3):314–319

    Article  PubMed  Google Scholar 

  15. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21–30

    Article  CAS  PubMed  Google Scholar 

  16. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta- analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15):2008–2012

    Article  CAS  PubMed  Google Scholar 

  17. Duckitt K, Harrington D (2005) Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ 330(7491):565

    Article  PubMed Central  PubMed  Google Scholar 

  18. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281

    Article  CAS  PubMed  Google Scholar 

  19. Abou-Raya S, Helmii M, Abou-Raya A (2009) Bone and mineral metabolism in older adults with Parkinson’s disease. Age Ageing 38(6):675–680

    Article  PubMed  Google Scholar 

  20. van den Bos F, Speelman AD, van Nimwegen M, van der Schouw YT, Backx FJ, Bloem BR, Munneke M, Verhaar HJ (2013) Bone mineral density and vitamin D status in Parkinson’s disease patients. J Neurol 260(3):754–760

    Article  CAS  PubMed  Google Scholar 

  21. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR (2013) Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology 81(17):1531–1537

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Evatt ML, Delong MR, Khazai N, Rosen A, Triche S, Tangpricha V (2008) Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol 65(10):1348–1352

    PubMed Central  PubMed  Google Scholar 

  23. Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliövaara M (2010) Serum vitamin D and the risk of Parkinson disease. Arch Neurol 67(7):808–811

    PubMed Central  PubMed  Google Scholar 

  24. Sato Y, Honda Y, Kaji M, Asoh T, Hosokawa K, Kondo I, Satoh K (2002) Amelioration of osteoporosis by menatetrenone in elderly female Parkinson’s disease patients with vitamin D deficiency. Bone 31(1):114–118

    Article  CAS  PubMed  Google Scholar 

  25. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Abnormal bone and calcium metabolism in immobilized Parkinson’s disease patients. Mov Disord 20(12):1598–1603

    Article  PubMed  Google Scholar 

  26. Egan KM, Signorello LB, Munro HM, Hargreaves MK, Hollis BW, Blot WJ (2008) Vitamin D insufficiency among African–Americans in the southeastern United States: implications for cancer disparities (United States). Cancer Causes Control 19(5):527–535

    Article  PubMed  Google Scholar 

  27. Tsiaras WG, Weinstock MA (2011) Factors influencing vitamin D status. Acta Derm Venereol 91(2):115–124

    PubMed  Google Scholar 

  28. Zhao Y, Sun Y, Ji HF, Shen L (2013) Vitamin D levels in Alzheimer’s and Parkinson’s diseases: a meta-analysis. Nutrition 29(6):828–832

    Article  CAS  PubMed  Google Scholar 

  29. Lawson DE, Paul AA, Black AE, Cole TJ, Mandal AR, Davie M (1979) Relative contributions of diet and sunlight to vitamin D state in the elderly. Br Med J 2(6185):303–305

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21–30

    Article  CAS  PubMed  Google Scholar 

  31. Buell JS, Dawson-Hughes B (2008) Vitamin D and neurocognitive dysfunction: preventing “D”ecline? Mol Aspects Med 29(6):415–422

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Han X, Xue L, Li Y, Chen B, Xie A (2012) Vitamin D receptor gene polymorphism and its association with Parkinson’s disease in Chinese Han population. Neurosci Lett 525(1):29–33

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Harbin Special Funds for Research of Scientific and Technological Innovative Talents (No. 2011RFQYS092) and Innovative Foundation of the Harbin Medical University (HCXS2010014).

Conflict of interest

The authors report no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Rehabilitation, the First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China

    Zheng Lv

  2. Department of Neurology, the Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, China

    Huiping Qi

  3. Department of Neurology, the First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China

    Le Wang, Xiaoxue Fan, Fei Han, Hong Wang & Sheng Bi

Authors
  1. Zheng Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Huiping Qi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Le Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiaoxue Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fei Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sheng Bi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sheng Bi.

Additional information

Z. Lv and H. Qi contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lv, Z., Qi, H., Wang, L. et al. Vitamin D status and Parkinson’s disease: a systematic review and meta-analysis. Neurol Sci 35, 1723–1730 (2014). https://doi.org/10.1007/s10072-014-1821-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-014-1821-6

Keywords

Search

Navigation