Neurological Sciences

, Volume 35, Supplement 1, pp 89–97

New treatments for headache

Key Note Lecture

DOI: 10.1007/s10072-014-1747-z

Cite this article as:
Vollbracht, S. & Rapoport, A.M. Neurol Sci (2014) 35: 89. doi:10.1007/s10072-014-1747-z


Migraine and cluster headache are primary headache disorders commonly encountered in clinical practice. Despite the profound disability caused by these primary headache disorders, available acute and preventive treatment options are limited. Recent understanding of headache pathophysiology has led to the development of new drug formulations and novel drug targets that are extremely promising. This article will highlight several of the new treatments that are currently under investigation including novel delivery mechanisms of already existing medications, calcitonin gene-related peptide (CGRP) receptor antagonists, antibodies to CGRP and its receptor, serotonin receptor agonists, transient receptor potential vanilloid receptor modulators, orexin receptor antagonists, glial cell modulators, and neuromodulation. If data is supportive, these therapies will be welcome additions to the headache specialist’s armamentarium.


Migraine treatmentHeadache therapy pipelineNovel delivery mechanismsCGRPNeuromodulation

Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  1. 1.Department of Neurology, Montefiore Headache CenterAlbert Einstein College of MedicineBronxUSA
  2. 2.The David Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.The International Headache Society PresidentLondonUnited Kingdom