Neurological Sciences

, Volume 35, Issue 5, pp 789–791

Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

  • Clara Guaschino
  • Federica Esposito
  • Giuseppe Liberatore
  • Bruno Colombo
  • Pietro Annovazzi
  • Emanuele D’Amico
  • Paola Cavalla
  • Elisabetta Capello
  • Ruggero Capra
  • Daniela Galimberti
  • Gioacchino Tedeschi
  • Luigi Grimaldi
  • PROGRESSO Group
  • PROGEMUS Group
  • Maurizio Leone
  • Sandra D’Alfonso
  • Vittorio Martinelli
  • Giancarlo Comi
  • Filippo Martinelli-Boneschi
Brief Communication

DOI: 10.1007/s10072-014-1650-7

Cite this article as:
Guaschino, C., Esposito, F., Liberatore, G. et al. Neurol Sci (2014) 35: 789. doi:10.1007/s10072-014-1650-7

Abstract

Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands’ clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

Keywords

Multiple sclerosisProgressiveRelapsing–remittingRecurrence risk

Supplementary material

10072_2014_1650_MOESM1_ESM.doc (24 kb)
Supplementary material 1 (DOC 24 kb)

Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  • Clara Guaschino
    • 1
  • Federica Esposito
    • 1
  • Giuseppe Liberatore
    • 1
  • Bruno Colombo
    • 1
  • Pietro Annovazzi
    • 2
  • Emanuele D’Amico
    • 3
  • Paola Cavalla
    • 4
  • Elisabetta Capello
    • 5
  • Ruggero Capra
    • 6
  • Daniela Galimberti
    • 7
  • Gioacchino Tedeschi
    • 8
  • Luigi Grimaldi
    • 9
  • PROGRESSO Group
  • PROGEMUS Group
  • Maurizio Leone
    • 10
  • Sandra D’Alfonso
    • 10
    • 11
  • Vittorio Martinelli
    • 1
  • Giancarlo Comi
    • 1
  • Filippo Martinelli-Boneschi
    • 1
  1. 1.Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific InstituteMilanItaly
  2. 2.Department of NeurologyS. Antonio Abate HospitalGallarateItaly
  3. 3.Department of Neurological SciencesUniversity of CataniaCataniaItaly
  4. 4.Department of NeurologyUniversity of TurinTurinItaly
  5. 5.Department of Neuroscience Ophthalmology and GeneticsUniversity of GenoaGenoaItaly
  6. 6.Multiple Sclerosis Centre, Spedali CiviliBresciaItaly
  7. 7.Department of Neurological Sciences, Centro Dino Ferrari, Fondazione Ca` Granda, Ospedale Maggiore PoliclinicoUniversity of MilanMilanItaly
  8. 8.Department of Neurological SciencesSecond University of NaplesNaplesItaly
  9. 9.Division of NeurologyFondazione Istituto San Raffaele “G. Giglio”CefalùItaly
  10. 10.MS CentreSCDU Neurology AOU Maggiore della CaritàNovaraItaly
  11. 11.Department of Health SciencesUniversity of Eastern PiedmontNovaraItaly