Neurological Sciences

, Volume 35, Issue 5, pp 789–791

Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

Authors

  • Clara Guaschino
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
  • Federica Esposito
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
  • Giuseppe Liberatore
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
  • Bruno Colombo
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
  • Pietro Annovazzi
    • Department of NeurologyS. Antonio Abate Hospital
  • Emanuele D’Amico
    • Department of Neurological SciencesUniversity of Catania
  • Paola Cavalla
    • Department of NeurologyUniversity of Turin
  • Elisabetta Capello
    • Department of Neuroscience Ophthalmology and GeneticsUniversity of Genoa
  • Ruggero Capra
    • Multiple Sclerosis Centre, Spedali Civili
  • Daniela Galimberti
    • Department of Neurological Sciences, Centro Dino Ferrari, Fondazione Ca` Granda, Ospedale Maggiore PoliclinicoUniversity of Milan
  • Gioacchino Tedeschi
    • Department of Neurological SciencesSecond University of Naples
  • Luigi Grimaldi
    • Division of NeurologyFondazione Istituto San Raffaele “G. Giglio”
  • PROGRESSO Group
  • PROGEMUS Group
  • Maurizio Leone
    • MS CentreSCDU Neurology AOU Maggiore della Carità
  • Sandra D’Alfonso
    • MS CentreSCDU Neurology AOU Maggiore della Carità
    • Department of Health SciencesUniversity of Eastern Piedmont
  • Vittorio Martinelli
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
  • Giancarlo Comi
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
    • Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of NeuroscienceInstitute of Experimental Neurology (INSPE), San Raffaele Scientific Institute
Brief Communication

DOI: 10.1007/s10072-014-1650-7

Cite this article as:
Guaschino, C., Esposito, F., Liberatore, G. et al. Neurol Sci (2014) 35: 789. doi:10.1007/s10072-014-1650-7

Abstract

Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands’ clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

Keywords

Multiple sclerosisProgressiveRelapsing–remittingRecurrence risk

Supplementary material

10072_2014_1650_MOESM1_ESM.doc (24 kb)
Supplementary material 1 (DOC 24 kb)

Copyright information

© Springer-Verlag Italia 2014