Neurological Sciences

, Volume 35, Issue 2, pp 307–316

Guidelines on the clinical use for the detection of neutralizing antibodies (NAbs) to IFN beta in multiple sclerosis therapy: report from the Italian Multiple Sclerosis Study group

  • Antonio Bertolotto
  • Marco Capobianco
  • Maria Pia Amato
  • Elisabetta Capello
  • Ruggero Capra
  • Diego Centonze
  • Maria Di Ioia
  • Antonio Gallo
  • Luigi Grimaldi
  • Luisa Imberti
  • Alessandra Lugaresi
  • Chiara Mancinelli
  • Maria Giovanna Marrosu
  • Lucia Moiola
  • Enrico Montanari
  • Silvia Romano
  • Luigina Musu
  • Damiano Paolicelli
  • Francesco Patti
  • Carlo Pozzilli
  • Silvia Rossi
  • Marco Salvetti
  • Gioachino Tedeschi
  • Maria Rosaria Tola
  • Maria Troiano
  • Mauro Zaffaroni
  • Simona Malucchi
Healthcare Organization

DOI: 10.1007/s10072-013-1616-1

Cite this article as:
Bertolotto, A., Capobianco, M., Amato, M.P. et al. Neurol Sci (2014) 35: 307. doi:10.1007/s10072-013-1616-1

Abstract

Interferon beta (IFNβ) was the first specific disease-modifying treatment licensed for relapsing-remitting multiple sclerosis, and is still one of the most commonly prescribed treatments. A strong body of evidence supports the effectiveness of IFNβ preparations in reducing the annual relapse rate, magnetic resonance (MRI) disease activity and disease progression. However, the development of binding/neutralizing antibodies (BAbs/NAbs) during treatment negatively affects clinical and MRI outcomes. Therefore, guidelines for the clinical use for the detection of NAbs in MS may result in better treatment of these patients. In October 2012, a panel of Italian neurologists from 17 MS clinics convened in Milan to review and discuss data on NAbs and their clinical relevance in the treatment of MS. In this paper, we report the panel’s recommendations for the use of IFNβ Nabs detection in the early identification of IFNβ non-responsiveness and the management of patients on IFNβ treatment in Italy, according to a model of therapeutically appropriate care.

Keywords

Multiple sclerosisIFNβNeutralizing antibodiesImmunogenicityGuidelines

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Antonio Bertolotto
    • 1
  • Marco Capobianco
    • 1
  • Maria Pia Amato
    • 2
  • Elisabetta Capello
    • 3
  • Ruggero Capra
    • 4
  • Diego Centonze
    • 5
  • Maria Di Ioia
    • 6
  • Antonio Gallo
    • 7
  • Luigi Grimaldi
    • 8
  • Luisa Imberti
    • 9
  • Alessandra Lugaresi
    • 6
  • Chiara Mancinelli
    • 10
  • Maria Giovanna Marrosu
    • 11
  • Lucia Moiola
    • 12
  • Enrico Montanari
    • 13
  • Silvia Romano
    • 14
  • Luigina Musu
    • 11
  • Damiano Paolicelli
    • 15
  • Francesco Patti
    • 16
  • Carlo Pozzilli
    • 10
  • Silvia Rossi
    • 5
  • Marco Salvetti
    • 14
  • Gioachino Tedeschi
    • 7
  • Maria Rosaria Tola
    • 17
  • Maria Troiano
    • 15
  • Mauro Zaffaroni
    • 18
  • Simona Malucchi
    • 1
  1. 1.Neurologia 2-CRESM, AOU San LuigiOrbassanoItaly
  2. 2.Section Neurosciences, Department NEUROFARBAUniversity of FlorenceFlorenceItaly
  3. 3.Departmento of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health (DINOGMI)University of GenoaGenoaItaly
  4. 4.Centro Sclerosi Multipla, Spedali CiviliBresciaItaly
  5. 5.Centro Sclerosi MultiplaUniversità Tor VergataRomeItaly
  6. 6.Dipartimento di Neuroscienze E Imaging, Centro Sclerosi MultiplaUniversità “G. d’Annunzio” ChietiChietiItaly
  7. 7.II Division of NeurologySecond University of NaplesNaplesItaly
  8. 8.U.O. di NeurologiaFondazione Istituto San Raffaele “G. Giglio” di CefalùCefalùItaly
  9. 9.CREA, Spedali Civili di BresciaBresciaItaly
  10. 10.MultipleSclerosis Center S.Andrea Hospital Dept. Neurology and PsychiatrySapienza UniversityRomeItaly
  11. 11.Dipartimento Sanità Pubblica Medicina Clinica e Molecolare, Centro Sclerosi Multipla, ASL 8Università di CagliariCagliariItaly
  12. 12.Neurological DepartmentSan Raffaele Scientific InstituteMilanItaly
  13. 13.Divisione di NeurologiaOspedale Civile di FidenzaParmaItaly
  14. 14.Neurology and Department of Neurosciences, Mental Health and Sensory Organs, Centre for Experimental Neurological Therapies (CENTERS)Sapienza UniversityRomeItaly
  15. 15.Department of Basic Medical Sciences, Neurosciences and Sense OrgansUniversity of Bari Aldo MoroBariItaly
  16. 16.Department of NeurosciencesUniversity of CataniaCataniaItaly
  17. 17.U.O. di Neurologia, Dipartimento Neuroscienze/RiabilitazioneAOU di FerraraFerraraItaly
  18. 18.Centro Studi Sclerosi MultiplaOspedale di GallarateGallarateItaly