Original Article

Neurological Sciences

, Volume 35, Issue 1, pp 73-77

First online:

The MTHFR C677T polymorphism modifies age at onset in Parkinson’s disease

  • Annamaria VallelungaAffiliated withMolecular Neurobiology Laboratory, IRCCS San Camillo Email author 
  • , Valentina PegoraroAffiliated withMolecular Neurobiology Laboratory, IRCCS San Camillo
  • , Manuela PilleriAffiliated withDepartment for Parkinson’s disease, IRCCS San Camillo
  • , Roberta BiundoAffiliated withDepartment for Parkinson’s disease, IRCCS San Camillo
  • , Angela De IuliisAffiliated withDepartment of Medical Sciences, University of Padua
  • , Mauro MarchettiAffiliated withDepartment of Developmental and Socialization Psychology, Faculty of Psychology, University of Padua
  • , Silvia FacchiniAffiliated withDepartment for Parkinson’s disease, IRCCS San Camillo
  • , Patrizia Formento DojotAffiliated withDepartment for Parkinson’s disease, IRCCS San Camillo
  • , Angelo AntoniniAffiliated withDepartment for Parkinson’s disease, IRCCS San Camillo

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Abstract

Hyperhomocysteinemia is a risk factor for Parkinson’s disease (PD) and may result from genetic mutations or/and environmental factors. 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. In this study we analyzed whether two functional polymorphisms of MTHFR gene, A1298C and C677T, affect age of onset in PD. We enrolled 120 patients with sporadic PD. Patients were divided into three groups based on MTHFR C677T polymorphisms: (a) homozygotes wild type (CC) (b) heterozygotes (CT) and (c) homozygotes carriers of mutation (TT). MTHFR SNPs were analyzed using High-Resolution Melt analysis and ANOVA was performed to assess whether polymorphisms of MTHFR gene could influence age of onset. The MTHFR A1298C polymorphism had no effect on PD age at onset (p = 1.0) while there was a significant association with MTHFR C677T (p = 0.019 Bonferroni-adjusted post hoc) showing an earlier onset in CC as compared with TT. (p = 0.024). No differences were found for vascular load assessed with magnetic resonance imaging, pharmacological therapy and cognitive state for two MTHFR SNPs. Our results suggest a possible association of MTHFR C677T with age at onset of PD and may have important implications regarding the role of MTHFR.

Keywords

Parkinson disease MTHFR C677T MTHFR A1298C Homocysteine Brain vascular load Age at onset of PD