Neurological Sciences

, Volume 34, Issue 9, pp 1509–1516

Peripheral polymorphonuclear leukocyte activation as a systemic inflammatory response in ischemic stroke

Review Article

DOI: 10.1007/s10072-013-1447-0

Cite this article as:
Mo, X., Li, T., Ji, G. et al. Neurol Sci (2013) 34: 1509. doi:10.1007/s10072-013-1447-0

Abstract

Stroke is one of the leading causes of mortality and morbidity in the world. The activation of polymorphonuclear leukocytes (PMNL) plays an important role in the inflammatory response after ischemic stroke. However, in the current literature, there are few studies discussing the process and role of peripheral PMNL activation. Here, we give a comprehensive description of peripheral PMNL activation after ischemic stroke and discuss their potential roles in the process of ischemic injury. Based on our analysis, peripheral PMNL activation is supposed to be attributed to systemic inflammatory response to cerebral ischemic insult, not reflecting the activity of PMNL in local ischemic brain. Inhibiting peripheral PMNL activation in stroke animals has been effective in reducing infarction and improving behavioral outcome; thus, the same approach of inhibiting peripheral PMNL activation is a promising therapeutic strategy for stroke patients.

Keywords

Polymorphonuclear leukocytePeripheralIschemic strokeSystemicInflammatory response

Abbreviations

PMNL

Polymorphonuclear leukocytes

TNF-α

Tumor necrosis factor-α

IL-1β

Interleukin-1 beta

IL-6

Interleukin-6

CAM

Cell adhesion molecules

PSGL-1

P-selectin glycoprotein ligand 1

SLe x

Sialyl Lewis x

CD11a

Cluster of differentiation molecule 11a

LFA-1

Lymphocyte function-associated antigen-1

Mac-1

Macrophage-1

ICAM-1

Intercellular adhesion molecule 1

VCAM-1

Vascular cell adhesion molecule 1

NGAL

Neutrophil gelatinase-associated lipocalin

NP4

Neutrophil proteinase 4

ROCK

Rho-associated protein kinase

CDC42

Cell division control protein 42

MACO

Middle cerebral artery occlusion

GM-CSF

Granulocyte–macrophage colony-stimulating factor

NIHSS

National Institutes of Health Stroke Scale

dMRI

Diffusion magnetic resonance imaging

CT

Computed tomography

MRI

Magnetic resonance imaging

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  1. 1.Department of NeurologySecond Xiangya Hospital, Central South UniversityChangshaPeople’s Republic of China