Neurological Sciences

, Volume 34, Issue 9, pp 1633–1637

Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical outcome of 462 cases

  • A. Ghezzi
  • P. Annovazzi
  • E. Cocco
  • G. Coarelli
  • A. Lugaresi
  • M. Rovaris
  • F. Patti
  • E. Capello
  • M. E. Rodegher
  • L. Moiola
  • S. Malucchi
  • G. Salemi
  • N. De Rossi
  • L. Provinciali
  • P. Perini
  • R. Bergamaschi
  • E. Scarpini
  • G. Lus
  • A. Gallo
  • M. R. Tola
  • M. P. Amato
  • M. R. Rottoli
  • A. Bianchi
  • G. Comi
  • The MS Study Group-Italian Society of Neurology
Original Article

DOI: 10.1007/s10072-013-1300-5

Cite this article as:
Ghezzi, A., Annovazzi, P., Cocco, E. et al. Neurol Sci (2013) 34: 1633. doi:10.1007/s10072-013-1300-5

Abstract

Although it is still debated whether chronic cerebro-spinal venous insufficiency (CCSVI) plays a role in multiple sclerosis (MS) development, many patients underwent endovascular treatment (ET) of CCSVI. The objective of the study is to evaluate the outcome and safety of ET in Italian MS patients. Italian MS centers that are part of the Italian MS Study Group were all invited to participate to this retrospective study. A structured questionnaire was used to collect detailed clinical data before and after the ET. Data from 462 patients were collected in 33 centers. ET consisted of balloon dilatation (93 % of cases) or stent application. The mean follow-up duration after ET was 31 weeks. Mean EDSS remained unchanged after ET (5.2 vs. 4.9), 144 relapses occurred in 98/462 cases (21 %), mainly in RR-MS patients. Fifteen severe adverse events were recorded in 3.2 % of cases. Given the risk of severe adverse events and the lack of objective beneficial effects, our findings confirm that at present ET should not be recommended to patients with MS.

Keywords

Multiple sclerosisCCSVIEndovascular treatment

Supplementary material

10072_2013_1300_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 14 kb)

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • A. Ghezzi
    • 1
  • P. Annovazzi
    • 1
  • E. Cocco
    • 2
  • G. Coarelli
    • 3
  • A. Lugaresi
    • 4
  • M. Rovaris
    • 5
  • F. Patti
    • 6
  • E. Capello
    • 7
  • M. E. Rodegher
    • 8
  • L. Moiola
    • 8
  • S. Malucchi
    • 9
  • G. Salemi
    • 10
  • N. De Rossi
    • 11
  • L. Provinciali
    • 12
  • P. Perini
    • 13
  • R. Bergamaschi
    • 14
  • E. Scarpini
    • 15
  • G. Lus
    • 16
  • A. Gallo
    • 17
  • M. R. Tola
    • 18
  • M. P. Amato
    • 19
  • M. R. Rottoli
    • 20
  • A. Bianchi
    • 1
  • G. Comi
    • 8
  • The MS Study Group-Italian Society of Neurology
  1. 1.Centro Studi Sclerosi Multipla, Ospedale di GallarateGallarateItaly
  2. 2.Centro Sclerosi Multipla, Dipartimento di Sanità Pubblica, Medicina Clinica e MolecolareUniversity of CagliariCagliariItaly
  3. 3.Centre for Experimental Neurological Therapies (CENTERS), Neurology and Department of Neurosciences, Mental Health and Sensory OrgansSapienza University S. Andrea Hospital-RomeRomeItaly
  4. 4.Multiple Sclerosis Center, Department of Neuroscience and ImagingUniversità “G d’Annunzio” ChietiChietiItaly
  5. 5.Multiple Sclerosis Center, Fondazione Don GnocchiMilanItaly
  6. 6.DANA GF Ingrassia, Neuroscience Section, Multiple Sclerosis CenterUniversity of CataniaCataniaItaly
  7. 7.Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child HealthUniversity of GenovaLiguriaItaly
  8. 8.Department of Neurology, San Raffaele Scientific InstituteVita-Salute San Raffaele UniversityMilanItaly
  9. 9.Neurologia 2-CRESM, AOU San Luigi GonzagaOrbassanoItaly
  10. 10.Centro per la “Diagnosi e Cura delle Malattie Demielinizzanti” Dipartimento di Biomedicina Sperimentale e Neuroscienze ClinicheUniversità degli Studi di PalermoPalermoItaly
  11. 11.U.S.D Neurologia, Centro Regionale per la Sclerosi Multipla, Spedali Civili Brescia, Presidio di MontichiariMontichiariItaly
  12. 12.Clinica NeurologicaUniversità Politecnica delle MarcheAnconaItaly
  13. 13.Neurological DepartmentAzienda Ospedaliera Università’ di PadovaPaduaItaly
  14. 14.Centro di Ricerca Interdipartimentale per la Sclerosi Multipla (CRISM), Istituto Neurologico Nazionale ‘C. Mondino’PaviaItaly
  15. 15.Clinica Neurologica, Fondazione Cà Granda Ospedale PoliclinicoMilanItaly
  16. 16.First Division of Neurology, Department of Clinical and Experimental Medicine and SurgerySecond University of NaplesNaplesItaly
  17. 17.II Clinica Neurologica, Dip.to di Scienze Mediche, Chirurgiche, Neurologiche, Metaboliche e dell’InvecchiamentoSeconda Università di NapoliNaplesItaly
  18. 18.Unità Operativa di Neurologia Azienda Ospedaliero, Universitaria S. Anna FerraraFerraraItlay
  19. 19.Department of NeurosciencesUniversity of FlorenceFlorenceItaly
  20. 20.Dipartimento di Chirurgia del Sistema Nervoso e Neuroscienze, Multiple Sclerosis CenterOspedali Riuniti BergamoBergamoItaly