Neurological Sciences

, Volume 34, Issue 9, pp 1591–1595

Plasma copeptin levels in Chinese patients with acute ischemic stroke: a preliminary study

  • Xiang Dong
  • Ding-Bo Tao
  • Ying-Xin Wang
  • Hong Cao
  • You-Song Xu
  • Qiu-Yan Wang
Original Article

DOI: 10.1007/s10072-013-1291-2

Cite this article as:
Dong, X., Tao, DB., Wang, YX. et al. Neurol Sci (2013) 34: 1591. doi:10.1007/s10072-013-1291-2

Abstract

Copeptin is a stable by-product of arginine-vasopressin synthesis and reflects its secretion. The objective of the study was to evaluate the predictive value of copeptine on functional outcome at 90-day follow-up from stroke onset. We conducted a prospective, observational cohort study in the emergency department of two hospitals and enrolled 125 patients with acute ischemic stroke. Plasma copeptin concentrations, determined by a CT-proAVP-luminescence-immunoassay, were measured. There was a good correlation between levels of plasma copeptin and NIHSS score (r = 0.733, P < 0.01). In the 41 patients (32.8 %) with a poor functional outcome, copeptin levels were higher compared with those in patients with a favorable outcome (27.3; IQR, 14.9–34.8 pmol/L vs. 12.9; IQR, 9.4–21.6 pmol/L; P < 0.0001). Copeptin levels in 18 patients who died were more than two times greater as compared to patients who survived (32.4; IQR, 18.7–38.5 pmol/L vs. 15.1; IQR, 12.4–24.6 pmol/L; P < 0.0001). After adjusting for all other significant outcome predictors, copeptin level remained an independent predictor for poor functional outcome and mortality with an odds ratio of 3.12 (95 % CI 1.54–6.46), 3.16 (95 % CI 0.92–6.15), respectively. Our study suggests that copeptin levels are a useful tool to predict outcome and mortality 3 months after acute ischemic stroke and have a potential to assist clinicians

Keywords

CopeptinAcute ischemic strokePrognostic biomarkerShort term

Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Xiang Dong
    • 1
  • Ding-Bo Tao
    • 1
  • Ying-Xin Wang
    • 1
  • Hong Cao
    • 1
  • You-Song Xu
    • 2
  • Qiu-Yan Wang
    • 3
  1. 1.Department of NeurologyFirst Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  2. 2.Department of NeurosurgeryFirst Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China
  3. 3.Department of EmergencyFirst Affiliated Hospital of Dalian Medical UniversityDalianPeople’s Republic of China