Neurological Sciences

, Volume 33, Issue 6, pp 1319–1327

Linguistic, psychometric validation and diagnostic ability assessment of an Italian version of a 19-item wearing-off questionnaire for wearing-off detection in Parkinson’s disease

  • Giovanni Abbruzzese
  • Angelo Antonini
  • Paolo Barone
  • Fabrizio Stocchi
  • Tiziano Tamburini
  • Laura Bernardi
  • Marianna Amboni
  • Laura Vacca
  • Valeria Posocco
  • Delia Colombo
Original Article

DOI: 10.1007/s10072-012-0943-y

Cite this article as:
Abbruzzese, G., Antonini, A., Barone, P. et al. Neurol Sci (2012) 33: 1319. doi:10.1007/s10072-012-0943-y

Abstract

A patient self-rated 19-item wearing-off questionnaire (WOQ-19) was shown to be a potent screening tool for wearing-off (WO) in patients with Parkinson’s disease. As part of the early detection of wearing-off in Parkinson’s disease study, we preliminarily performed a linguistic and a psychometric validation of an Italian version of the WOQ-19. Moreover, we assessed the sensitivity and specificity of the WOQ-19 in the office-based settings. The psychometric validation study included assessment of discriminant ability, internal consistency and test–retest reliability. The intraclass correlation coefficient (ICC) and the Cronbach’s Alpha were assessed. The WOQ-19 sensitivity and specificity were calculated in respect to the physician assessment of WO, taken as the gold standard. The Italian version of WOQ-19 was found easy to understand by ≥80% of the patients. The number of WO-related symptoms detected by WOQ-19 was 7.5 ± 3.2 in patients with WO and 1.6 ± 2.6 in patients without WO (p < 0.0001). Cronbach’s alpha was equal to 0.868 for the total number of WO symptoms. The ICC value was equal to 0.858 for WO-related symptoms as a whole. The diagnostic ability study recruited 207 patients: for a WOQ-19 cut-off ≥2, the sensitivity was equal to 0.881 and the specificity was 0.674. This is the first validation of WOQ-19 in Italian, with excellent linguistic validity and psychometric properties. WOQ-19 was confirmed to be reliable in WO detection.

Keywords

Parkinson’s disease Wearing-off Motor fluctuations Non-motor fluctuations Wearing-off patient questionnaire 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Giovanni Abbruzzese
    • 1
  • Angelo Antonini
    • 2
  • Paolo Barone
    • 3
  • Fabrizio Stocchi
    • 4
  • Tiziano Tamburini
    • 1
  • Laura Bernardi
    • 2
  • Marianna Amboni
    • 5
  • Laura Vacca
    • 4
  • Valeria Posocco
    • 6
  • Delia Colombo
    • 6
  1. 1.Department of NeurosciencesUniversity of GenoaGenoaItaly
  2. 2.Department for Parkinson’s DiseaseIRCCS San CamilloVeniceItaly
  3. 3.Scuola Medica SalernitanaUniversità degli Studi di SalernoSalernoItaly
  4. 4.Department of NeurologyInstitute of Research and Medical Care, IRCCS San RaffaeleRomeItaly
  5. 5.Department of Neurological SciencesUniversity of Napoli Federico II-IDC Hermitage CapodimonteNaplesItaly
  6. 6.Medical DepartmentNovartis Farma ItaliaOriggioItaly

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