Original Article

Neurological Sciences

, Volume 32, Issue 4, pp 609-613

Memantine attenuates the impairment of spatial learning and memory of pentylenetetrazol-kindled rats

  • Li-Jing JiaAffiliated withDepartment of Neurology, The Second Hospital of Hebei Medical University
  • , Wei-Ping WangAffiliated withDepartment of Neurology, The Second Hospital of Hebei Medical University Email author 
  • , Zhou-Ping LiAffiliated withDepartment of Neurology, The Second Hospital of Hebei Medical University
  • , Jun-Li ZhenAffiliated withDepartment of Neurology, The Second Hospital of Hebei Medical University
  • , Li-Wei AnAffiliated withDepartment of Neurology, The Second Hospital of Hebei Medical University
  • , Rui-Sheng DuanAffiliated withDepartment of Neurology, The Second Hospital of Hebei Medical University

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Abstract

Cognitive disorders after epilepsy can have a great impact on the quality of life of epileptic patients, though it has not drawn much attention. Even after identified, it is often undertreated or has gone untreated. Memantine has been approved to treat moderate to severe Alzheimer disease (AD), which is characterized by cognitive impairment. In present study, we determined the effects of memantine on PTZ-kindled rats, which can mimic the postseizure dysfunction that resembles symptoms observed in human epilepsy. We found that memantine can ameliorate the spatial learning and memory of epileptic rats. But contrary to previous claims that memantine can improve cognition in AD patients, without serious side effects on normal learning and memory abilities, we found that rats treated only with memantine exhibited the impaired spatial learning and memory ability. We conclude that memantine can improve cognition related to an excitotoxicity-induced pathologic state, but the potential side effects of memantine on the physiological processes should be considered.

Keywords

Epilepsy Cognition Spatial learning and memory Kindling Memantine Pentylenetetrazol