Neurological Sciences

, Volume 32, Issue 2, pp 361–363

Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study

  • Maria Pia Giannoccaro
  • Vincenzo Donadio
  • Carolina Gomis Pèrez
  • Walter Borsini
  • Vitantonio Di Stasi
  • Rocco Liguori
Letter to the Editor

DOI: 10.1007/s10072-010-0475-2

Cite this article as:
Giannoccaro, M.P., Donadio, V., Gomis Pèrez, C. et al. Neurol Sci (2011) 32: 361. doi:10.1007/s10072-010-0475-2

Abstract

Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.

Keywords

Small fiber neuropathy Bortezomib Velcade Autonomic neuropathy Skin biopsy 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Maria Pia Giannoccaro
    • 1
  • Vincenzo Donadio
    • 1
  • Carolina Gomis Pèrez
    • 1
  • Walter Borsini
    • 2
  • Vitantonio Di Stasi
    • 1
  • Rocco Liguori
    • 1
  1. 1.Dipartimento di Scienze NeurologicheUniversità di BolognaBolognaItaly
  2. 2.Dipartimento di Scienze Neurologiche e PsichiatricheUniversità di Firenze, Ospedale CareggiFlorenceItaly