Key Note Lecture

Neurological Sciences

, Volume 31, Issue 1, pp 129-132

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

New acute treatments for headache

  • Alan M. RapoportAffiliated withThe David Geffen School of Medicine at UCLA Email author 


Although we have several acute care medications for the treatment of migraine, we are always looking for new medications to treat our patients. Patients often say that their headaches are not under optimal control and would be happy to try another medication. Patients look for faster onset of relief, more complete relief, no recurrent headache and no adverse events. This article will cover some new and some anticipated acute care products, CGRP antagonists, sumatriptan by iontophoretic patch, sumatriptan by needle-free injections, DHE by oral inhalation and diclofenac potassium in a sachet. Botulinum toxin therapy, although a preventive measure, will be mentioned at the end.


Acute treatment of migraine Migraine therapy CGRP antagonist Iontophoretic patch Needle free injection Sumatriptan DHE Oral inhalation