Neurological Sciences

, Volume 31, Issue 6, pp 693–697

Systemic thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke: first Croatian experiences

Authors

  • Vesna Matijević
    • Department of Neurology University Hospital Center Zagreb
  • Domagoj Alvir
    • Department of Neurology University Hospital Center Zagreb
  • Branko Malojčić
    • Department of Neurology University Hospital Center Zagreb
    • Department of NeurologySchool of Medicine, University of Zagreb
  • Lea Unušić
    • Department of Neurology University Hospital Center Zagreb
  • Svjetlana Šupe
    • Department of Neurology University Hospital Center Zagreb
  • Marina Boban
    • Department of Neurology University Hospital Center Zagreb
    • Department of NeurologySchool of Medicine, University of Zagreb
  • Andrea Bujan-Kovač
    • Department of Neurology University Hospital Center Zagreb
    • Department of Neurology University Hospital Center Zagreb
    • Department of NeurologySchool of Medicine, University of Zagreb
  • Zdravka Poljaković
    • Department of Neurology University Hospital Center Zagreb
    • Department of NeurologySchool of Medicine, University of Zagreb
Original Article

DOI: 10.1007/s10072-010-0237-1

Cite this article as:
Matijević, V., Alvir, D., Malojčić, B. et al. Neurol Sci (2010) 31: 693. doi:10.1007/s10072-010-0237-1

Abstract

In September 2003, recombinant tissue plasminogen activator (rt-PA) for acute treatment of ischemic stroke was finally approved by the Croatian Ministry of Health. For the next 5 years, only three stroke units in the country implemented this therapy in their routine practice until summer 2008, when neurological wards in most Croatian hospitals started to treat acute stroke patients with systemic thrombolysis. We present a 2-year experience of thrombolytic therapy (2006–2008) in the stroke unit of the University Hospital in Zagreb, Croatian largest hospital, serving nearly one-fifth of the citizens of Croatia. Obtained data (vitals at admission and before administration of rt-PA; NIHSS and MRS scores at admission, 2 h and 7th day after rt-PA treatment, “time to door” and “door to needle” intervals, duration of hospital treatment as well as outcomes and complications of our 66 thrombolysed patients) are presented and discussed. We also present our results regarding benefits of this therapy as well as possible reasons for complications noticed.

Keywords

StrokeThrombolysisrt-PA

Copyright information

© Springer-Verlag 2010