Neurological Sciences

, Volume 31, Issue 3, pp 381–385

The effect of l-Dopa administration on pursuit ocular movements in suspected Parkinson’s disease

  • Silvia Marino
  • Pietro Lanzafame
  • Edoardo Sessa
  • Alessia Bramanti
  • Placido Bramanti
Brief Communication

DOI: 10.1007/s10072-009-0180-1

Cite this article as:
Marino, S., Lanzafame, P., Sessa, E. et al. Neurol Sci (2010) 31: 381. doi:10.1007/s10072-009-0180-1

Abstract

The objective of this study is to evaluate pursuit ocular movements (POM) by using a vision-based non-intrusive eye tracker, in patients with suspected Parkinson’s disease (PD), before and after l-Dopa administration. We studied ten patients with suspected diagnosis of idiopathic PD. We compared POM values to those of a group of normal controls (NC), and evaluated them before and after l-Dopa administration. Unified Parkinson’s Disease Rating Scale (UPDRS) motor subscores improved significantly (p = 0.001). At baseline, values of POM were lower in suspected PD patients than in NC (p = 0.01). One hour after l-Dopa administration, POM values correlated with UPDRS motor subscore (p = 0.01). We used a recent method, a new vision-based non-intrusive eye tracker, previously described, which can be proposed as a possible tool for supporting the diagnosis of PD in association with levodopa test, as an add-on to the UPDRS score.

Keywords

l-Dopa Parkinson disease Pursuit ocular movements Vision-based eye-tracking system 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Silvia Marino
    • 1
  • Pietro Lanzafame
    • 1
  • Edoardo Sessa
    • 1
  • Alessia Bramanti
    • 1
  • Placido Bramanti
    • 1
  1. 1.IRCCS Centro Neurolesi, “Bonino-Pulejo”MessinaItaly

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