Neurological Sciences

, Volume 30, Issue 3, pp 219–226

Decreased bilateral cortical representation patterns in writer’s cramp: a functional magnetic resonance imaging study at 3.0 T

  • Tina Islam
  • Andreas Kupsch
  • Harald Bruhn
  • Christian Scheurig
  • Sein Schmidt
  • Karl-Titus Hoffmann
Original Article

DOI: 10.1007/s10072-009-0045-7

Cite this article as:
Islam, T., Kupsch, A., Bruhn, H. et al. Neurol Sci (2009) 30: 219. doi:10.1007/s10072-009-0045-7

Abstract

Functional magnetic resonance imaging was used to characterize patterns of cortical activation in response to sensory and motor tasks in patients with writer’s cramp. 17 patients and 17 healthy subjects were examined during finger-tapping, index finger flexion, and electrical median nerve stimulation of both hands during electromyographic monitoring. SPM2 was used to evaluate Brodmann area (BA) 4, 1, 2, 3, 6, 40. Patients showed decreased activation in the left BA 4 with motor tasks of both hands and the left BA 1–3 with right finger-tapping. With left finger-tapping there was bilateral underactivation of single areas of the somatosensory cortex. Patients exhibited decreased activation in the bilateral BA 6 with left motor tasks and in the right BA 6 with right finger-tapping. Patients had decreased activation in bilateral BA 40 with finger-tapping of both hands. The findings suggest decreased baseline activity or an impaired activation in response to motor tasks in BA 1–4, 6, 40 in patients with writer’s cramp for the dystonic and the clinically unaffected hand.

Keywords

Functional magnetic resonance imaging Dystonia Writer’s cramp Brain activation study 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Tina Islam
    • 1
    • 3
  • Andreas Kupsch
    • 2
  • Harald Bruhn
    • 1
  • Christian Scheurig
    • 1
  • Sein Schmidt
    • 2
  • Karl-Titus Hoffmann
    • 1
  1. 1.Department of RadiologyCharite University Medical SchoolBerlinGermany
  2. 2.Department of NeurologyCharite University Medical SchoolBerlinGermany
  3. 3.Department of RadiologyMassachusetts General HospitalBostonUSA