Neurological Sciences

, Volume 30, Issue 3, pp 251–254

Neoplastic meningitis from breast carcinoma with complete response to liposomal cytarabine: case report

  • Paola Gaviani
  • A. Silvani
  • E. Corsini
  • A. Erbetta
  • A. Salmaggi
Case Report

DOI: 10.1007/s10072-009-0044-8

Cite this article as:
Gaviani, P., Silvani, A., Corsini, E. et al. Neurol Sci (2009) 30: 251. doi:10.1007/s10072-009-0044-8

Abstract

Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte®) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte).

Keywords

Neoplastic meningitis Breast carcinoma Chemotherapy Liposomal cytarabine 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Paola Gaviani
    • 1
  • A. Silvani
    • 1
  • E. Corsini
    • 2
  • A. Erbetta
    • 3
  • A. Salmaggi
    • 1
  1. 1.Neuro Oncology DepartmentFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly
  2. 2.Laboratory of Clinical AnalysesFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly
  3. 3.Neuroradiology DepartmentFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly

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