Neurological Sciences

, Volume 29, Supplement 2, pp 277–278

Renin-angiotensin system and stroke

Authors

  • Simona Marcheselli
    • Neurologia I e Stroke UnitIRCCS Istituto Clinico Humanitas
    • Neurologia I e Stroke UnitIRCCS Istituto Clinico Humanitas
Annual Meeting of SIN/SNO Lombardia

DOI: 10.1007/s10072-008-0963-9

Cite this article as:
Marcheselli, S. & Micieli, G. Neurol Sci (2008) 29: 277. doi:10.1007/s10072-008-0963-9

Abstract

The renin-angiotensin system (RAS) is a major regulatory system of cardiovascular and renal function. Many new aspects of this system have been revealed in recent years, leading to new therapeutic approaches. It’s well known that RAS blocking agents have potent antiatherosclerotic effects, which are mediated by their antihypertensive, anti-inflammatory, antiproliferative, and oxidative stress lowering properties. Inhibitors of RAS are now first-line treatments for hypertensive target organ damage. Their effects are greater than expected by their ability to lower blood pressure. Angiotensin receptor blockers reduce the frequency of atrial fibrillation and stroke, are also able to prevent cardiovascular and renal events in diabetic patients. Thus, blockade of RAS represents one of the most important strategies in order to reduce cardiovascular risk.

Keywords

AngiotensinStrokeACE-inhibitorAngiotensin II type 1 receptors blocking agent
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Copyright information

© Springer-Verlag Italia 2008