Density and cross-sectional areas of axons in the olfactory tract in control subjects and Alzheimer’s disease: an image analysis study
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Using an image analysis system to determine whether there is loss of axons in the olfactory tract (OT) in Alzheimer’s disease (AD).
A retrospective neuropathological study.
Nine control patients and eight clinically and pathologically verified AD cases.
Measurements and Results
There was a reduction in axon density in AD compared with control subjects in the central and peripheral regions of the tract. Axonal loss was mainly of axons with smaller (<2.99 μm2) myelinated cross-sectional areas.
The data suggest significant degeneration of axons within the OT involving the smaller sized axons. Loss of axons in the OT is likely to be secondary to pathological changes originating within the parahippocampal gyrus rather than to a pathogen spreading into the brain via the olfactory pathways.
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- Density and cross-sectional areas of axons in the olfactory tract in control subjects and Alzheimer’s disease: an image analysis study
Volume 29, Issue 1 , pp 23-27
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- Alzheimer’s disease
- Olfactory tract
- Axon density
- Axon cross-sectional area
- Parahippocampal gyrus
- Corpora amylacea
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