Neurological Sciences

, Volume 28, Issue 4, pp 165–170

Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke

  • V. Lucivero
  • M. Prontera
  • D. M. Mezzapesa
  • M. Petruzzellis
  • M. Sancilio
  • A. Tinelli
  • D. Di Noia
  • M. Ruggieri
  • F. Federico
Original

DOI: 10.1007/s10072-007-0814-0

Cite this article as:
Lucivero, V., Prontera, M., Mezzapesa, D.M. et al. Neurol Sci (2007) 28: 165. doi:10.1007/s10072-007-0814-0

Abstract

Accumulating data suggest that matrix metalloproteinases (MMPs), in particular MMP-2 and MMP-9, are deleterious after acute ischaemic stroke. A beneficial effect of MMPs in the repairing phases of cerebral ischaemia has also been proposed. This study investigated the relationship between MMP-2 and MMP-9 and stroke subtypes, clinical recovery and haemorrhagic transformation (HT). We measured MMP-9 and MMP-2 plasma levels in 29 patients with ischaemic stroke at days one and seven. MMP-2 levels increased only in lacunar strokes, whilst MMP-9 increased only in patients with more severe stroke. Basal MMP-2 levels were higher in patients with stable or recovering symptoms whilst MMP-9 values at day seven were correlated with worse clinical outcome. No differences related to the presence of HT were found. This study sustains a different behaviour of MMPs after ischaemic stroke. MMP-2 seems to be expressed early and related to better outcome, whilst MMP-9 seems to be late and related to more severe stroke.

Key words

Matrix metalloproteinases Acute ischaemic stroke 

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • V. Lucivero
    • 1
  • M. Prontera
    • 1
  • D. M. Mezzapesa
    • 1
  • M. Petruzzellis
    • 1
  • M. Sancilio
    • 1
  • A. Tinelli
    • 1
  • D. Di Noia
    • 1
  • M. Ruggieri
    • 1
  • F. Federico
    • 1
  1. 1.Department of Neurological and Psychiatric SciencesUniversity of BariBariItaly