Neurological Sciences

, Volume 28, Issue 3, pp 121–126

Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta

Original

DOI: 10.1007/s10072-007-0803-3

Cite this article as:
Saraste, M., Irjala, H. & Airas, L. Neurol Sci (2007) 28: 121. doi:10.1007/s10072-007-0803-3

Abstract

We studied how interferon-beta (IFN-β) treatment of relapsing-remitting multiple sclerosis (MS) affects subgroups of natural killer cells (NK cells). Following IFN-β treatment, there was an expansion of CD56Bright NK-cells in the peripheral blood of MS patients, while at the same time the proportion of CD56Dim cells was diminished. In a control group, the proportion of CD56Bright NK-cells was significantly higher in secondary lymphoid tissues compared to the peripheral blood of the same individual. Our findings confirm that CD56Bright NK-cells preferably locate within the secondary lymphoid tissues, where they may interact with T cells and thereby contribute to the control of the disease activity in MS.

Key words

Interferon-betaMultiple sclerosisNK cell

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  1. 1.MediCity Research LaboratoryUniversity of TurkuTurkuFinland
  2. 2.Department of OtorhinolaryngologyUniversity of TurkuTurkuFinland
  3. 3.Department of NeurologyUniversity of TurkuTurkuFinland