Neurological Sciences

, Volume 28, Supplement 2, pp S217–S219

Headache and anxiety–depressive disorder comorbidity: the HADAS study

  • E. Beghi
  • G. Allais
  • P. Cortelli
  • D. D'Amico
  • R. De Simone
  • F. d'Onofrio
  • S. Genco
  • G. C. Manzoni
  • F. Moschiano
  • M. C. Tonini
  • P. Torelli
  • M. Quartaroli
  • M. Roncolato
  • S. Salvi
  • G. Bussone
ORAL COMMUNCATION

DOI: 10.1007/s10072-007-0780-6

Cite this article as:
Beghi, E., Allais, G., Cortelli, P. et al. Neurol Sci (2007) 28: S217. doi:10.1007/s10072-007-0780-6

Abstract

Psychiatric comorbidity (prevalence and types) was tested in a naturalistic sample of adult patients with pure migraine without aura, and in two control groups of patients, one experiencing pure tension-type headache and the other combined migraine and tension-type headaches. The study population included 374 patients (158, 110 and 106) from nine Italian secondary and tertiary centres. Psychiatric comorbidity was recorded through structured interview and also screened with the Mini International Neuropsychiatry Interview (MINI). Only anxiety and depression were investigated. Psychiatric disorders were reported by 49 patients (14.6%; 10.9% of patients with migraine, 12.8% of those with tension-type headache and 21.4% of those with combined migraine and tension-type headaches). The MINI interview detected a depressive episode in 59.9% of patients with migraine, 68.3% of patients with tension-type headache and 69.6% of patients with combined migraine and tension-type headaches. Depression subtypes were significantly different across groups (p=0.03). Anxiety (mostly generalised) was reported by 18.4% of patients with migraine, 19.3% of patients with tension-type headache, and 18.4% of patients with combined migraine and tension-type headaches. The values for panic disturbance were 12.7, 5.5 and 14.2, and those for obsessive–compulsive disorders were 2.3, 1.1 and 9.4% (p=0.009). Based on these results, psychopathology of primary headache can be a reflection of the burden of the disease rather than a hallmark of a specific headache category.

Key words

HeadacheMigraineTension-type headacheDepressionAnxiety

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • E. Beghi
    • 1
  • G. Allais
    • 2
  • P. Cortelli
    • 3
  • D. D'Amico
    • 4
  • R. De Simone
    • 5
  • F. d'Onofrio
    • 6
  • S. Genco
    • 7
  • G. C. Manzoni
    • 8
  • F. Moschiano
    • 9
  • M. C. Tonini
    • 11
  • P. Torelli
    • 8
  • M. Quartaroli
    • 10
  • M. Roncolato
    • 10
  • S. Salvi
    • 10
  • G. Bussone
    • 4
  1. 1.Istituto Laboratorio di Malattie Neurologiche Mario NegriMilanItaly
  2. 2.Centro Cefalee Della Donna, Dipartimento Discipline Ginecologiche ed OstetricheUniversità degli studi di TorinoItaly
  3. 3.Dipartimento di ScienzeNeurologiche Università degli Studi di BolognaItaly
  4. 4.Dipartimento Neuroscienze ClinicheFondazione IRCCS Istituto Neurologico C. BestaMilanItaly
  5. 5.Centro Cefalee Dipartimento di Scienze NeurologicheUniversità Federico IINaplesItaly
  6. 6.Unità Operativa Complessa di NeurologiaAzienda Ospedaliera “SG Moscati”AvellinoItaly
  7. 7.Clinica Neurologica IAzienda Ospedaliera – Policlinico BariItaly
  8. 8.Centro Cefalee Sezione di Neurologia - Dipartimento di NeuroscienzeUniversità degli Studi di PaviaItaly
  9. 9.Unità Operativa Neurologia e Stroke UnitAz. Osp. Prov. di Lecco - Presidio di Merate (LC)Italy
  10. 10.Direzione Medica GSKVeronaItaly
  11. 11.Centro Cefalee Ospedale “G. Salvini”Garbagnate Milanese (MI)Italy