ORIGINAL

Neurological Sciences

, Volume 24, Issue 5, pp 318-321

First online:

Prophylactic treatment of episodic cluster headache with intravenous bolus of methylprednisolone

  • P. MirAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , R. AlbercaAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , A. NavarroAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , E. MontesAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , E. MartínezAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , E. FrancoAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , A. CayuelaAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío
  • , P. LozanoAffiliated withDepartment of Neurology, University Hospital Virgen del Rocío

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Abstract.

We evaluated the efficacy of intravenous boluses of methylprednisolone followed by prednisone as a prophylactic treatment for episodic cluster headache. Fourteen male patients (mean age, 42.54 years) with episodic cluster headache were treated with 250-mg boluses of methylprednisolone on 3 consecutive days, followed by prednisone (90 mg/day orally) with gradual tapering in four weeks. Headache parameters of the active phases treated with methylprednisolone were compared with those of previous active phases in the same patients treated with other prophylactic medications. The primary efficacy criterion was decrease in the frequency of attacks during the first month of treatment. The statistical differences were calculated using Wilcoxon’s test. The attacks were significantly less frequent in the active phases treated with methylprednisolone boluses than those treated with other medications (p<0.05). This treatment seems to be more effective than the usual prophylactic treatments for episodic cluster headache.

Key words

Cluster headache Steroids Methylprednisolone Prophylactic treatment