Neurological Sciences

, Volume 24, Supplement 4, pp s239–s243

Rasmussen’s syndrome

Authors

  • T. Granata
    • Department of Child NeurologyNational Neurological Institute “C. Besta”
MULTIPLE SCLEROSIS AND RARE PATHOLOGIES

DOI: 10.1007/s10072-003-0086-2

Cite this article as:
Granata, T. Neurol Sci (2003) 24: s239. doi:10.1007/s10072-003-0086-2

Abstract.

Rasmussen’s encephalitis (RE) is characterized by focal seizures, often associated with epilepsia partialis continua, progressive neurological deterioration, hemispheric atrophy, and inflammatory histopathology. Surgical exclusion of the affected hemisphere is the only treatment that halts progression of the disease. The possible role played by serum antibodies against the glutamate receptor GluR3 in the animal model and in a number of affected patients supports a disimmune component in the pathogenesis of the disease and provides a rational basis for considering the use of immunomodulatory treatments in selected cases. The use of intravenous immunoglobulins has produced encouraging results in adultonset RE but further studies are needed to assess the effect, dosage, and schedules in childhood-onset RE.

Key words

Epilepsy Autoimmunity Immunoglobulin Immunomodulation

Copyright information

© Springer-Verlag Italia 2003