Research Note

Food Science and Biotechnology

, Volume 19, Issue 4, pp 1119-1122

First online:

Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

  • Nguyen Huu TungAffiliated withCollege of Pharmacy, Chungnam National University
  • , Seok Bean SongAffiliated withCollege of Pharmacy, Chungnam National University
  • , Gyu Yong SongAffiliated withCollege of Pharmacy, Chungnam National University
  • , Jeong-Ah KimAffiliated withCollege of Pharmacy, Chungnam National University
  • , Jung-Eun KooAffiliated withSchool of Medicine and Brain Korea 21 Program, Jeju National University
  • , Hee-Kyoung KangAffiliated withSchool of Medicine and Brain Korea 21 Program, Jeju National University
  • , Young-Sang KohAffiliated withSchool of Medicine and Brain Korea 21 Program, Jeju National University
  • , Young Ho KimAffiliated withCollege of Pharmacy, Chungnam National University Email author 

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Abstract

Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopolysaccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.

Keywords

interleukin-12 Panax ginseng ginsenoside bone marrow-derived dendritic cell