Food Science and Biotechnology

, Volume 19, Issue 4, pp 1119–1122

Inhibitory effect of ginsenosides from ginseng leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells

Authors

  • Nguyen Huu Tung
    • College of PharmacyChungnam National University
  • Seok Bean Song
    • College of PharmacyChungnam National University
  • Gyu Yong Song
    • College of PharmacyChungnam National University
  • Jeong-Ah Kim
    • College of PharmacyChungnam National University
  • Jung-Eun Koo
    • School of Medicine and Brain Korea 21 ProgramJeju National University
  • Hee-Kyoung Kang
    • School of Medicine and Brain Korea 21 ProgramJeju National University
  • Young-Sang Koh
    • School of Medicine and Brain Korea 21 ProgramJeju National University
    • College of PharmacyChungnam National University
Research Note

DOI: 10.1007/s10068-010-0159-y

Cite this article as:
Tung, N.H., Song, S.B., Song, G.Y. et al. Food Sci Biotechnol (2010) 19: 1119. doi:10.1007/s10068-010-0159-y

Abstract

Ginseng leaves and flowers have been known to be rich in various ginsenosides. The aim of present study is to screen the effect of 34 ginsenosides from ginseng leaves and flowers on interlukin (IL)-12 production in bone marrow-derived dendritic cells induced by lipopolysaccharide (LPS). Noticeably, floralginsenoside Kc (5), floralginsenoside J (26), and ginsenoside I (33) exhibited particularly inhibitory effect on LPS-induced IL-12 production with IC50 values of 16.3, 25.8, and 6.7 μM, respectively. In addition, floralginsenoside Kc (5) suppressed significantly LPS-stimulated IL-6 and tumor necrosis factor-α (TNF-α) production. These results warrant further studies concerning potential of saponin extracts of Panax ginseng leaves and flowers for medicinal foods.

Keywords

interleukin-12Panax ginsengginsenosidebone marrow-derived dendritic cell

Copyright information

© The Korean Society of Food Science and Technology and Springer Netherlands 2010