Clinical Rheumatology

, Volume 20, Issue 3, pp 177–180

Static Lung Compliance as an Index of Early Pulmonary Disease in Systemic Sclerosis

  • A. Sud
  • D. Gupta
  • A. Wanchu
  • S. K. Jindal
  • P. Bambery
Original Article

DOI: 10.1007/s100670170060

Cite this article as:
Sud, A., Gupta, D., Wanchu, A. et al. Clin Rheumatol (2001) 20: 177. doi:10.1007/s100670170060

Abstract:

Pulmonary function abnormalities constitute the most important cause of morbidity and mortality in patients with systemic sclerosis (SSc). A restrictive ventilatory defect with a reduction in pulmonary carbon monoxide diffusion capacity (DLCO) is the commonest finding. Static lung compliance (Cst) is perhaps the most sensitive parameter for the detection of abnormal pulmonary mechanics. We compared the results of Cst and DLCO in patients with SSc and normal spirometry to identify early pulmonary disease. Sixteen of 50 patients had normal spirometry, eight of whom had abnormal Cst. Four of them also had a reduced DLCO. Two patients had abnormal DLCO but their Cst was normal. One of them had pulmonary hypertension on echocardiography. We conclude that Cst was helpful in diagnosing early pulmonary abnormality in 50% of patients with normal spirometry. Among these patients Cst was a better index of abnormality than DLCO.

Key words:Progressive systemic sclerosis – Pulmonary fibrosis – Scleroderma 

Copyright information

© Clinical Rheumatology 2001

Authors and Affiliations

  • A. Sud
    • 1
  • D. Gupta
    • 1
  • A. Wanchu
    • 1
  • S. K. Jindal
    • 1
  • P. Bambery
    • 1
  1. 1.Post Graduate Institute of Medical Education and Research, Chandigarh, IndiaIN

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