Clinical Rheumatology

, Volume 18, Issue 3, pp 220–226

Juvenile Chronic Arthritis in Adult Life: A Study of Long-term Outcome in Patients with Juvenile Chronic Arthritis or Adult Rheumatoid Arthritis

  • R. Koivuniemi
  • M. Leirisalo-Repo
Original Article

DOI: 10.1007/s100670050088

Cite this article as:
Koivuniemi, R. & Leirisalo-Repo, M. Clin Rheumatol (1999) 18: 220. doi:10.1007/s100670050088


We compared the prognostic factors and outcome of 30 patients with juvenile chronic arthritis (JCA) extending into adult life with those of 30 patients with adult rheumatoid arthritis (RA) at a university adult rheumatology clinic; pairs were matched for sex and duration of disease (mean 8 years). One-third of JCA patients had seronegative polyarticular disease and another third had oligoarticular disease. In a third of the JCA patients, the clinical presentation changed during the follow-up. Over half of the RA patients had seropositive polyarticular and a one-third had seronegative polyarticular disease. Fewer seropositive patients were recorded in the JCA group than in the RA group both at the beginning (16.7% versus 56.7%; p = 0.003) and at the end of the follow-up (14.3% versus 59.3%; p = 0.001). JCA patients developed less radiographic changes than RA patients (46.7% versus 76.7%; p = 0.034); oligoarthritis in the JCA group had the best prognosis whereas seropositive polyarthritis in the RA group had the worst prognosis. Significantly more patients with JCA than RA (60% versus 23%; p = 0.009) were in remission at the end of the follow-up. In conclusion, when studied in adult life, the long-term prognosis is better in patients with JCA than in those with RA.

Key words:Juvenile chronic arthritis – Prognosis – Rheumatoid arthritis

Copyright information

© Clinical Rheumatology 1999

Authors and Affiliations

  • R. Koivuniemi
    • 1
  • M. Leirisalo-Repo
    • 1
  1. 1.Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, FinlandFI