Clinical Rheumatology

, Volume 33, Issue 6, pp 763–767

Does the microbiome play a causal role in spondyloarthritis?

  • James T. Rosenbaum
  • Phoebe Lin
  • Mark Asquith
  • Mary-Ellen Costello
  • Tony J. Kenna
  • Matthew A. Brown
Original Article

DOI: 10.1007/s10067-014-2664-5

Cite this article as:
Rosenbaum, J.T., Lin, P., Asquith, M. et al. Clin Rheumatol (2014) 33: 763. doi:10.1007/s10067-014-2664-5

Abstract

The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.

Keywords

Inflammatory bowel diseaseMicrobiomeSpondyloarthritis

Copyright information

© Clinical Rheumatology 2014

Authors and Affiliations

  • James T. Rosenbaum
    • 1
    • 2
  • Phoebe Lin
    • 1
  • Mark Asquith
    • 1
  • Mary-Ellen Costello
    • 3
  • Tony J. Kenna
    • 3
  • Matthew A. Brown
    • 3
  1. 1.Division of Arthritis and Rheumatic Diseases and Department of OphthalmologyOregon Health & Science UniversityPortlandUSA
  2. 2.Legacy Devers Eye InstitutePortlandUSA
  3. 3.The University of Queensland Diamantina Institute, Princess Alexandra HospitalUniversity of QueenslandBrisbaneAustralia