, Volume 31, Issue 1, pp 13-21,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 09 Nov 2011

An update on the pathology and clinical management of gouty arthritis

Abstract

Gouty arthritis is an inflammatory condition associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality of life. This condition is initially triggered by the deposition of monosodium urate crystals into the joint space. This causes an inflammatory cascade resulting in the secretion of several proinflammatory cytokines and neutrophil recruitment into the joint. While generally effective, currently available agents are associated with a number of adverse events and contraindications that complicate their use. Based on our increased understanding of the inflammatory pathogenesis of gouty arthritis, several new agents are under development that may provide increased efficacy and reduced toxicity.

The author had full control of the contents, and the opinions expressed here are those of the author and not of Novartis Pharmaceuticals Corporation.