Clinical Rheumatology

, Volume 30, Issue 10, pp 1373–1378

Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population

  • Qi Wu
  • Bo Yu
  • Yuewen Chen
  • Yong Shao
  • Jie Zhang
  • Qili Zhong
  • Xi Peng
  • Hong Yang
  • Xiaoping Hu
  • Bancheng Chen
  • Ming Guan
  • Jun Wan
  • Wei Zhang
Brief Report

DOI: 10.1007/s10067-011-1794-2

Cite this article as:
Wu, Q., Yu, B., Chen, Y. et al. Clin Rheumatol (2011) 30: 1373. doi:10.1007/s10067-011-1794-2

Abstract

Systemic lupus erythematosus (SLE) is a complex immune disease affected by both genetic dispositions and environmental factors. Recently, the polymorphisms in MAMDC1 gene have been reported to associate with disease risk of SLE in European population. However, whether this association is replicated in Chinese population is unknown yet. A total of 491 SLE patients and 533 controls were recruited. Unlabeled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabeled probe successfully distinguished all genotypes. SNP rs961616 was associated with rash [P = 0.015, odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.57–0.94] and photosensitivity (P = 0.001, OR = 0.63, 95%CI = 0.48–0.84), but not the disease risk (P = 0.133, OR = 0.88, 95%CI = 0.74–1.04), of SLE in Chinese population. Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population.

Keywords

High-resolution melting analysis (HRMA)MAMDC1Single-nucleotide polymorphisms (SNPs)Systemic lupus erythematosus (SLE)

Copyright information

© Clinical Rheumatology 2011

Authors and Affiliations

  • Qi Wu
    • 1
    • 2
    • 3
  • Bo Yu
    • 2
    • 3
    • 4
  • Yuewen Chen
    • 5
  • Yong Shao
    • 2
    • 3
    • 4
  • Jie Zhang
    • 2
    • 4
  • Qili Zhong
    • 2
    • 4
  • Xi Peng
    • 2
    • 4
  • Hong Yang
    • 2
    • 3
  • Xiaoping Hu
    • 2
    • 4
  • Bancheng Chen
    • 2
    • 4
  • Ming Guan
    • 6
  • Jun Wan
    • 2
    • 3
    • 7
  • Wei Zhang
    • 5
    • 7
  1. 1.Department of Biochemistry, Peking University Health Science CenterPeking UniversityPekingChina
  2. 2.Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical CenterShenzhenChina
  3. 3.Biomedical Research Institute, Shenzhen-PKU-HKUST Medical CenterShenzhenChina
  4. 4.Department of DermatologyShenzhen Hospital Peking UniversityShenzhenChina
  5. 5.JNU-HKUST Joint LabJi-Nan UniversityGuangzhouChina
  6. 6.Department of Clinical LaboratoryHuashan HospitalShanghaiChina
  7. 7.Division of Life ScienceThe Hong Kong University of Science and TechnologyHong KongChina