Clinical Rheumatology

, Volume 30, Issue 10, pp 1373–1378

Single-nucleotide polymorphisms of MAMDC1 are associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese mainland population

Authors

  • Qi Wu
    • Department of Biochemistry, Peking University Health Science CenterPeking University
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center
  • Bo Yu
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Yuewen Chen
    • JNU-HKUST Joint LabJi-Nan University
  • Yong Shao
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Jie Zhang
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Qili Zhong
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Xi Peng
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Hong Yang
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center
  • Xiaoping Hu
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Bancheng Chen
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Department of DermatologyShenzhen Hospital Peking University
  • Ming Guan
    • Department of Clinical LaboratoryHuashan Hospital
    • Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center
    • Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center
    • Division of Life ScienceThe Hong Kong University of Science and Technology
    • JNU-HKUST Joint LabJi-Nan University
    • Division of Life ScienceThe Hong Kong University of Science and Technology
Brief Report

DOI: 10.1007/s10067-011-1794-2

Cite this article as:
Wu, Q., Yu, B., Chen, Y. et al. Clin Rheumatol (2011) 30: 1373. doi:10.1007/s10067-011-1794-2

Abstract

Systemic lupus erythematosus (SLE) is a complex immune disease affected by both genetic dispositions and environmental factors. Recently, the polymorphisms in MAMDC1 gene have been reported to associate with disease risk of SLE in European population. However, whether this association is replicated in Chinese population is unknown yet. A total of 491 SLE patients and 533 controls were recruited. Unlabeled probe-based high-resolution melting analysis (HRMA) was used in genotyping. HRMA with unlabeled probe successfully distinguished all genotypes. SNP rs961616 was associated with rash [P = 0.015, odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.57–0.94] and photosensitivity (P = 0.001, OR = 0.63, 95%CI = 0.48–0.84), but not the disease risk (P = 0.133, OR = 0.88, 95%CI = 0.74–1.04), of SLE in Chinese population. Polymorphisms of rs961616 in MAMDC1 gene were associated with rash and photosensitivity, but not disease risk, of systemic lupus erythematosus in Chinese population.

Keywords

High-resolution melting analysis (HRMA)MAMDC1Single-nucleotide polymorphisms (SNPs)Systemic lupus erythematosus (SLE)

Copyright information

© Clinical Rheumatology 2011