Clinical Rheumatology

, Volume 30, Issue 7, pp 959–965

Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis

  • Chih-Te Charles Wu
  • Liang-Shiou Ou
  • Kuo-Wei Yeh
  • Wen-I Lee
  • Jing-Long Huang
Original Article

DOI: 10.1007/s10067-011-1709-2

Cite this article as:
Wu, CT.C., Ou, LS., Yeh, KW. et al. Clin Rheumatol (2011) 30: 959. doi:10.1007/s10067-011-1709-2

Abstract

Heat shock protein (Hsp) 60 has been implicated in the pathogenesis of various inflammatory and autoimmune diseases. This study aimed to investigate synovial fluid and serum concentrations of Hsp60 and anti-Hsp60 and their relationship with juvenile idiopathic arthritis (JIA). Forty-eight patients with JIA, including 22 oligo-articular, 19 poly-articular, and 7 systemic diseases, and 33 normal controls were enrolled in this study. Synovial fluid and serum Hsp60 and anti-Hsp60 concentrations were measured via ELISA. Serum concentrations of Hsp60 of active and inactive oligo- and poly-articular JIA were significantly higher than those of normal controls. Serum concentration of anti-Hsp60 in active oligo-articular JIA was higher than that of normal controls (49.25 vs. 35.76 ng/mL, p = 0.059). Similarly, serum concentration of anti-Hsp60 in active poly-articular JIA was significantly higher than that of inactive samples (65.05 vs. 26.54 ng/mL, p = 0.008). In addition, serum concentration of Hsp60 correlated with the time required for remission from flare-ups in patients with JIA. Serum concentration of Hsp60 correlated well with time required for remission from flare-ups in patients with JIA, representing a potential disease marker to monitor disease activity.

Keywords

Heat shock proteinJuvenile idiopathic arthritisRegulatory T cell

Abbreviations

Hsp

Heat shock protein

JIA

Juvenile idiopathic arthritis

Treg

Regulatory T cells

TLR

Toll-like receptor

CD

Cluster of differentiation

APC

Antigen-presenting cells

MyD88

Myeloid differentiation factor 88

TIR

Toll/interleukin-1 receptor

TIRAP

TIR domain-containing adaptor

TRIF

TIR domain-containing adapter-inducing interferon-β

PBMC

Peripheral blood-derived mononuclear cells

IL

Interleukin

IFN

Interferon

Copyright information

© Clinical Rheumatology 2011

Authors and Affiliations

  • Chih-Te Charles Wu
    • 1
  • Liang-Shiou Ou
    • 1
  • Kuo-Wei Yeh
    • 1
  • Wen-I Lee
    • 1
  • Jing-Long Huang
    • 1
  1. 1.Division of Allergy, Asthma, and Rheumatology, Department of PediatricsChang Gung Memorial Hospital and Chang Gung UniversityKueishanTaiwan