Clinical Rheumatology

, Volume 29, Issue 6, pp 677–681

Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-α therapy: a case series

  • Kimberly Morishita
  • Ross Petty
  • Robyn Cairns
  • Roxana Bolaria
  • David Cabral
  • Stuart Turvey
Brief Report

DOI: 10.1007/s10067-010-1410-x

Cite this article as:
Morishita, K., Petty, R., Cairns, R. et al. Clin Rheumatol (2010) 29: 677. doi:10.1007/s10067-010-1410-x

Abstract

Anti-tumor necrosis factor-α (anti-TNF-α) agents are widely used to treat children with juvenile idiopathic arthritis (JIA) whose disease is resistant to conventional therapy. Although generally well tolerated, use of these agents has been associated with an increased risk of infection. In particular, in patients treated with anti-TNF-α agents, there is an increased susceptibility to infection by intracellular organisms such as tuberculosis, and common infections may present atypically or be more severe. We report four cases of serious musculoskeletal infections among 31 children with JIA being treated with anti-TNF-α agents, two of which were secondary to group A β-hemolytic Streptococcus.

Keywords

Anti-tumor necrosis factor-αBiologicsInfectionsJuvenile idiopathic arthritis

Copyright information

© Clinical Rheumatology 2010

Authors and Affiliations

  • Kimberly Morishita
    • 1
    • 5
  • Ross Petty
    • 1
  • Robyn Cairns
    • 4
  • Roxana Bolaria
    • 3
  • David Cabral
    • 1
  • Stuart Turvey
    • 2
  1. 1.Division of Rheumatology, British Columbia’s Children’s HospitalUniversity of British ColumbiaVancouverCanada
  2. 2.Division of Infectious and Immunological Diseases, British Columbia’s Children’s HospitalUniversity of British ColumbiaVancouverCanada
  3. 3.Department of Pediatrics, British Columbia’s Children’s HospitalUniversity of British ColumbiaVancouverCanada
  4. 4.Department of Radiology, British Columbia’s Children’s HospitalUniversity of British ColumbiaVancouverCanada
  5. 5.Division of RheumatologyBritish Columbia’s Children’s HospitalVancouverCanada