Clinical Rheumatology

, Volume 29, Issue 7, pp 815–818

Renal cortical necrosis at presentation in a patient with systemic lupus erythematosus: an autopsy case report

Authors

    • Department of PathologyNizam’s Institute of Medical Sciences
  • Liza Rajasekhar
    • Department of RheumatologyNizam’s Institute of Medical Sciences
  • H. Swetha
    • Department of PathologyNizam’s Institute of Medical Sciences
  • V. R. Srinivasan
    • Department of General MedicineNizam’s Institute of Medical Sciences
  • Aruna K. Prayaga
    • Department of PathologyNizam’s Institute of Medical Sciences
Case Report

DOI: 10.1007/s10067-010-1395-5

Cite this article as:
Uppin, M.S., Rajasekhar, L., Swetha, H. et al. Clin Rheumatol (2010) 29: 815. doi:10.1007/s10067-010-1395-5

Abstract

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there was Libmann–Sacks endocarditis with multiorgan infarcts and renal cortical necrosis. Secondary antiphospholipid antibodies contribute to the cardiac and renal manifestations in SLE. We discuss the incidence and pathogenesis of endocarditis with differential diagnosis for cortical necrosis in a patient of SLE.

Keywords

CAPSRenal cortical necrosisSLE

Copyright information

© Clinical Rheumatology 2010