Renal cortical necrosis at presentation in a patient with systemic lupus erythematosus: an autopsy case report
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- Uppin, M.S., Rajasekhar, L., Swetha, H. et al. Clin Rheumatol (2010) 29: 815. doi:10.1007/s10067-010-1395-5
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Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there was Libmann–Sacks endocarditis with multiorgan infarcts and renal cortical necrosis. Secondary antiphospholipid antibodies contribute to the cardiac and renal manifestations in SLE. We discuss the incidence and pathogenesis of endocarditis with differential diagnosis for cortical necrosis in a patient of SLE.