Clinical Rheumatology

, 28:1453

Leflunomide for the successful management of juvenile Cogan's syndrome

Case Report

DOI: 10.1007/s10067-009-1263-3

Cite this article as:
Xie, L., Cai, Y., Bao, X. et al. Clin Rheumatol (2009) 28: 1453. doi:10.1007/s10067-009-1263-3


Cogan's syndrome (CS) is a rare multisystemic disorder characterized by inflammatory eye diseases and vestibuloauditory dysfunctions. It is prone to be misdiagnosed or overlooked, and the prognosis of those delayed-diagnosed CS is not optimistic. Despite isolated patient responses to systemic treatment including steroids and methotrexate, there is currently no general consensus on an effective treatment for CS. We present a case of Cogan's syndrome remission associated with leflunomide (LEF) in a juvenile patient. To date, there is no such report on CS, especially in children, which is successfully treated by LEF in combination with glucocorticoids.


Autoimmune diseases Cogan's syndrome Juvenile Leflunomide 

Copyright information

© Clinical Rheumatology 2009

Authors and Affiliations

  1. 1.Department of Pediatrics, Renji HospitalShanghai Jiaotong UniversityShanghaiChina
  2. 2.Department of Radiation Oncology, Cancer HospitalFudan UniversityShanghaiChina
  3. 3.Department of Neurosurgery, Huashan HospitalFudan UniversityShanghaiChina

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