Clinical Rheumatology

, Volume 28, Issue 6, pp 693–697

Anti-dsDNA antibodies in Brazilian patients of mainly African descent with systemic lupus erythematosus: lack of association with lupus nephritis

  • A. M. Atta
  • M. M. Pereira
  • M. Santiago
  • M. L. B. Sousa-Atta
Original Article

DOI: 10.1007/s10067-009-1134-y

Cite this article as:
Atta, A.M., Pereira, M.M., Santiago, M. et al. Clin Rheumatol (2009) 28: 693. doi:10.1007/s10067-009-1134-y

Abstract

Renal disease is associated with morbidity and mortality in systemic lupus erythematosus (SLE) and anti-dsDNA antibodies with SLE immunopathogenesis. We investigated the dsDNA antibody profile of 84 Brazilian SLE patients, 27 with lupus nephritis. Thirty-six (39.1%) patients had dsDNA IgG antibodies shown in enzyme-linked immunosorbent assay (454.7 ± 281.1 WHO units/mL), nine presenting renal disease. The following profile of dsDNA antibodies was demonstrated in Crithidia luciliae test: IgA (seven out of 36; 19.4%), IgG (22 out of 36, 66.1%); IgM (nine out of 36, 25.0%), and IgE (four out of 36, 11.1%). Two or three isotypes of dsDNA antibodies were observed in nine (25.0%) patients, while 11 (30.5%) were seronegative in the C. luciliae test. Patients with dsDNA antibodies had lower serum C3 and C4 when compared with SLE individuals without these immunoglobulins (P < 0.01 and P < 0.001, respectively). There was no association between any dsDNA antibody isotype and lupus kidney disease nor was anti-dsDNA IgM antibody associated with absence of nephritis.

Keywords

BrazildsDNA antibodyIsotypeNephritisSystemic lupus erythematosus

Copyright information

© Clinical Rheumatology 2009

Authors and Affiliations

  • A. M. Atta
    • 1
    • 3
  • M. M. Pereira
    • 1
  • M. Santiago
    • 2
  • M. L. B. Sousa-Atta
    • 1
  1. 1.Departamento de Análises Clínicas e Toxicológicas, Faculdade de FarmáciaUniversidade Federal da BahiaSalvador, BahiaBrazil
  2. 2.Serviço de Reumatologia do Hospital Santa IzabelEscola Bahiana de Medicina e Saúde Pública (EBMSP)Salvador, BahiaBrazil
  3. 3.Faculdade de Farmácia da UFBASalvador, BahiaBrazil