, Volume 28, Issue 4, pp 385-389

Quantitative alterations of CD8+ T cells in juvenile idiopathic arthritis patients in remission

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The study was aimed to investigate whether quantities of CD8+ T cell subsets are normal in juvenile idiopathic arthritis (JIA) patients with disease remission compared to age-matched healthy donors (HD) and whether chronological age may have an impact on proportions of naive CD8+ T cells. CD8+ T cell subsets were analyzed in 17 JIA patients and 32 age-matched HD by flow cytometry. JIA patients showed lower CD3+CD8+ T cells compared to HD. Total counts of CD8+CD28+ and CD8+CD28+CD45RA+ T cells were inversely correlated to chronological age in JIA patients and HD. In JIA patients, percentages of CD8+CD28+CD45RA+ T cells and of CD62L-expressing CD8+CD28+CD45RA+ T cells showed a negative correlation with age. The trend to lower CD28+CD45RA+ T cell proportions in aged JIA patients in remission may reflect a disturbed T cell homeostasis independently of disease activity and may be due to an intrinsic effect in reconstitution of the peripheral T cells.