Clinical Rheumatology

, Volume 28, Issue 2, pp 145–151

Haemoglobin levels are associated with bone mineral density in the elderly: a population-based study

Authors

    • Department of Gerontology and GeriatricsCatholic University of Medicine
  • Emanuele Marzetti
    • Biochemistry of Aging Laboratory, Department of Aging and Geriatrics, College of Medicine, Division of Biology of Aging, Institute on AgingUniversity of Florida
  • Francesco Pagano
    • Department of Gerontology and GeriatricsCatholic University of Medicine
  • Roberto Bernabei
    • Department of Gerontology and GeriatricsCatholic University of Medicine
  • Giuseppe Zuccalà
    • Department of Gerontology and GeriatricsCatholic University of Medicine
Original Article

DOI: 10.1007/s10067-008-0998-6

Cite this article as:
Laudisio, A., Marzetti, E., Pagano, F. et al. Clin Rheumatol (2009) 28: 145. doi:10.1007/s10067-008-0998-6

Abstract

Hypoxemia has been associated with low bone mineral density (BMD) in animal and human models. We assessed the association of haemoglobin levels with ultrasound-derived (UD) T score, Z score and the stiffness index in all 358 subjects aged 75+ living in Tuscania (Italy). Also, we searched for the haemoglobin cutoff levels that might best identify participants with osteoporosis. In the multivariable linear regression analysis, haemoglobin levels were associated among participants with the UD T score [β = 0.13; 95% confidence interval (CI) = 0.01–0.25; p = 0.030], Z score (β = 0.11; 95% CI = 0.01–0.22; p = 0.045) and stiffness index (β = 1.87; 95% CI = 0.51–3.21; p = 0.007) after adjusting for potential confounders. Haemoglobin levels <140 g/L in men and <130 g/L in women best predicted osteoporosis in linear discriminant analysis. Haemoglobin is independently associated with all UD-BMD parameters. Haemoglobin levels <140 g/L in men and 130 g/L in women might be adopted in clinical practice to identify older subjects in whom screening for osteoporosis might yield higher effectiveness.

Keywords

ElderlyEpidemiologyHaemoglobinOsteoporosis

Copyright information

© Clinical Rheumatology 2008